Hotels in Cayo Guillermo makes it easy and rewarding. Always

  • hcom rewards loyalty icon
    Reward yourself your way
    Stay where you want, when you want, and get rewarded
  • hcom mod icon
    Unlock instant savings
    Save an average of 15% on thousands of hotels with Member Prices
  • today icon
    Free cancellation
    Flexible bookings on most hotels*

Where to stay in Cayo Guillermo?

Find out more about Cayo Guillermo

Frequently asked questions

What accommodations do travelers recommend in Cayo Guillermo?
Guests like Hotel Grand Muthu Cayo Guillermo, Iberostar Daiquirí - All inclusive and Sol Cayo Guillermo - All Inclusive.
Where can I get free parking with my stay in Cayo Guillermo?
Villa Gregorio offers the perk of free parking.
Can I book a refundable accommodation in Cayo Guillermo?
If you want the flexibility to change your travel plans to Cayo Guillermo, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Cayo Guillermo?
Your furry friend can stay with you at this pet-friendly hotel: Sol Cayo Guillermo - All Inclusive.
Where should I stay in Cayo Guillermo if I want a cheap accommodation?
An inexpensive option worth considering is Villa Gregorio.
Where can I stay if I'm visiting Cayo Guillermo with my children?
Your kids are welcome at Hotel Grand Muthu Cayo Guillermo and Villa Gregorio.
Where should I stay in Cayo Guillermo if I want a luxury hotel?
An option for a luxury stay is Iberostar Daiquirí.
What will the weather in Cayo Guillermo be like during my vacation?
With an average temperature of 76°F during the coldest months, Cayo Guillermo is a great place to visit any time of year.
Why should I book my Cayo Guillermo accommodation with
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on, Expedia and Vrbo.