This is more like a B&B than a hotel, in that it is basically a part of someone's residence. It is located in a residential neighborhood and is about a 10 minute walk from a major mall. In Guayaquil, location is not all-important because of the wide availability of taxis at a low cost. We recommend using the Easy Taxi app.
The service at El Patio is excellent! Delia Robinson, the owner, and her daughter picked us up from the airport at about 1 AM. Our room was basically a studio apartment with an efficiency kitchen and two twin beds. It had granite countertops, nice cabinetry, AC, and was clean and well decorated. The rain head shower provided nice warm water, but it really only came out at a trickle. That was a bit of a minus. The beds were fairly comfortable but not like at a high-end hotel.
The one big drawback, and it wasn't a huge problem for us because I'm a heavy sleeper and my wife wears ear plugs, is that the place is right in the flight path of the nearby military airbase. A few times each night and several times each day there are large aircraft taking off and, with some windows being permanently open to the outside, it is extremely loud when they fly over.
Considering all of these factors, plus the price, I would recommend El patio suites and would consider staying there again if in Guayaquil.