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Southeast Missouri hotels

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Hotels in Southeast Missouri

What's Southeast Missouri like?

Southeast Missouri is a family-friendly place known for its restaurants. Nature lovers can explore top areas such as Ozark National Scenic Riverways and Shawnee National Forest. Popular sights like Isle Casino Cape Girardeau and Lady Luck Casino won't disappoint.

Where are the best places to stay in Southeast Missouri?

Here are our travelers' top 5 places to stay in Southeast Missouri:

Hampton Inn Cape Girardeau I 55 East

2.5-star Cape Girardeau hotel with indoor pool
  • • Free breakfast • Free parking • Free WiFi • Fitness center • Comfy beds

Drury Plaza Hotel Cape Girardeau Conference Center

3-star hotel with indoor pool, 24-hour fitness center
  • • Free breakfast • Free parking • Free WiFi • Restaurant • Central location

Holiday Inn Express Hotel & Suites Cape Girardeau I-55

2.5-star Cape Girardeau hotel with indoor pool
  • • Free buffet breakfast • Free parking • Free WiFi • Fitness center • Central location

Holiday Inn Express & Suites Perryville

Hotel with indoor pool, near National Shrine of Our Lady of the Miraculous Medal
  • • Free breakfast • Free parking • Free WiFi • 24-hour fitness center • Central location

Echo Bluff State Park

Mountain hotel within easy reach of Echo Bluff State Park
  • • Free parking • Free WiFi • Restaurant • 24-hour front desk • Central location

What types of hotels are available in Southeast Missouri?

We have 163 Southeast Missouri accommodations.

Things to See and Do in Southeast Missouri

What is there to see in Southeast Missouri?

  • • Ozark National Scenic Riverways
  • • Shawnee National Forest
  • • Clearwater Lake
  • • Taum Sauk Mountain State Park
  • • Elephant Rocks State Park

What is there to do in Southeast Missouri?

  • • Isle Casino Cape Girardeau
  • • Lady Luck Casino
  • • Powder Mill Cave Natural Area
  • • Sikeston Depot Museum
  • • Kennett Country Club

Other Popular Southeast Missouri Attractions

  • • St. Joe State Park
  • • Mark Twain National Forest
  • • Fort Davidson State Historic Site
  • • The Heritage House
  • • Hawn State Park

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