Hotels in Sancti Spiritu

Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Check prices for these dates

Tonight
Apr 27 - Apr 28
Tomorrow
Apr 28 - Apr 29
Next weekend
May 2 - May 4
In two weeks
May 9 - May 11

Where to stay in Sancti Spiritu?

A tranquil hotel pool encircled by beautiful arches

Summer Getaway Sale

Sign in to get 25% or more off selected hotels, plus 1 reward night for every 10 nights you stay. Book by May 26 and travel by Sep 30, 2025. See terms*
Sign in or join for free

Frequently asked questions

Can I book a refundable accommodation in Sancti Spiritu?
If you’re looking for the flexibility to change your travel plans to Sancti Spiritu, most properties provide refundable* rates you can book. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Sancti Spiritu be like during my visit?
The warmest months in Sancti Spiritu are usually January and December with an average temp of 74°F. July and June are the chilliest months when the average temp is 54°F. The rainiest months are January and February.
Why should I book my Sancti Spiritu hotel through Hotels.com?
There are lots of reasons to book your Sancti Spiritu trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Sancti Spiritu

Find out more about Sancti Spiritu

If you're looking to discover somewhere new, look no further than Sancti Spiritu. Whether you're planning to stay for a night or for the week, the area around Sancti Spiritu has accommodations to fit every need. Search for hotels in Sancti Spiritu with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Sancti Spiritu hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Sancti Spiritu hotel deals are here with our lowest price guarantee.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com™ app users and Hotels.com™ Rewards members. Limited availability, blackout periods may apply.

Hotels.com Rewards members save more, as compared to non-members shopping on Hotels.com. Members 18+. Eligible properties only. Reward Night worth average daily rate of 10 stamps (excluding taxes/fees). Taxes/fees payable on reward night. Booking exclusions apply, see terms https://ca.hotels.com/lp/b/terms-of-service?pos=HCOM_CA&locale=en_CA.