Hotels in Cayo Guillermo

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Where to stay in Cayo Guillermo?

Top landmarks in Cayo Guillermo

Learn more about Cayo Guillermo

The region around Cayo Guillermo is home to attractions such as Cayo Guillermo Beach and Cayo Guillermo Marina.

A tranquil hotel pool encircled by beautiful arches

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Frequently asked questions

Can I book a refundable accommodation in Cayo Guillermo?
If you want the flexibility to change your travel plans to Cayo Guillermo, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Cayo Guillermo?
Your furry friend can stay with you at this pet-friendly hotel: Sol Cayo Guillermo - All Inclusive.
Where can I stay if I'm visiting Cayo Guillermo with my children?
Parents traveling with children may want to consider Iberostar Daiquirí - All inclusive.
Where should I stay in Cayo Guillermo for a getaway with my partner?
Sol Cayo Guillermo - All Inclusive and Iberostar Daiquirí - All inclusive are great options for a romantic getaway.
Where should I stay in Cayo Guillermo if I want a luxury hotel?
An option for a luxury stay is Iberostar Daiquirí.
What will the weather in Cayo Guillermo be like during my vacation?
With an average temperature of 76°F during the coldest months, Cayo Guillermo is a great place to visit any time of year.
Why should I book my Cayo Guillermo accommodation with Hotels.com?
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Cayo Guillermo

Find out more about Cayo Guillermo

Unveil the Untamed Beauty of Cayo Guillermo: A Hidden Paradise Awaits

Cayo Guillermo, nestled in the Province of Ciego de Ávila, Cuba, is a tropical paradise that enchants with its pristine white-sand beaches and crystal-clear turquoise waters. Renowned for its vibrant coral reefs and rich marine life, this idyllic destination offers exceptional snorkeling and diving opportunities. Nature lovers can explore the nearby Cayo Coco and its stunning landscapes, while the luxurious Sol Cayo Guillermo resort provides a perfect backdrop for romantic getaways. Whether lounging on the beach or indulging in water sports, Cayo Guillermo promises an unforgettable escape into nature's embrace. For great hotel rates in Cayo Guillermo, be sure to check out Hotels.com's Last-Minute DealsOpens in a new window on travel.

Top locations to stay in Cayo Guillermo

Some of the best places to stay in Cayo Guillermo are Cayo Coco and Cayo Ensenachos. Cayo Coco and Cayo Ensenachos are both stunning destinations for travellers seeking beautiful beaches and vibrant marine life. Cayo Coco offers a range of all-inclusive resorts that cater to families and couples, while Cayo Ensenachos boasts more exclusive accommodations, ideal for a serene getaway. For first-time visitors, Cayo Coco is recommended due to its accessibility and variety of activities. Both locations feature comfortable hotels that provide excellent amenities for a relaxing stay in Cuba. Here are some of our travelers' favorite hotels in Cayo Guillermo:

  1. Cayo CocoOpens in a new window: Cayo Coco is a stunning destination celebrated for its beautiful beaches and vibrant natural parks, making it perfect for beach lovers and adventure seekers alike. Notable attractions include Cayo Coco Beach and Parque Natural el Bagá, which offers breathtaking scenery and outdoor activities. For accommodation, consider Aparthotel AzulOpens in a new window, a 2.5-star hotel featuring a coffee shop, bar, and restaurant, along with entertainment options like satellite and LCD TVs. Another option is Aparthotel AzulOpens in a new window, which caters to pet owners, allowing dogs and cats onsite. Lastly, Sitio La GuiraOpens in a new window, also a 2.5-star hotel, offers free cooked breakfast and a restaurant, combined with cable and regular television to keep you entertained.
  2. Cayo EnsenachosOpens in a new window: Known for its striking scenery and pristine beaches, Cayo Ensenachos is a tranquil escape for families and nature enthusiasts. With attractions like Caibarien Beach and Cayo Guillermo Beach, it’s a great spot for relaxation and cultural exploration, including the Camilo Cienfuegos National Museum. Grand Memories Santa Maria - All InclusiveOpens in a new window is a 3.5-star all-inclusive resort, offering unlimited food and drinks, direct beach access, and a range of amenities for children, including a free kids' club. Alternatively, Sanctuary at Grand Memories Santa Maria - Adults Only - All InclusiveOpens in a new window, another 3.5-star all-inclusive resort, also provides direct access to the beach and a variety of adventure sports such as kayaking and snorkeling, making it ideal for adventure-seeking travellers.

Things to do in Cayo Guillermo for first times

Cayo Guillermo is a stunning tropical paradise, renowned for its pristine beaches and vibrant ecosystems. Travellers can enjoy activities like boating, snorkelling, and wildlife tours, all set against a backdrop of lush greenery and tranquil waters. This idyllic destination promises relaxation and adventure, making it a must-visit for nature lovers. Here's a quick itinerary to make the most of your trip to Cayo Guillermo:

  • Cayo Guillermo Beach: Renowned for its stunning white sands and crystal-clear turquoise waters, Cayo Guillermo Beach is the ideal spot for sunbathing, swimming, and relaxing. The beach offers a tranquil atmosphere, making it perfect for families and couples alike. You can also engage in various water sports, such as snorkeling and kayaking, to explore the vibrant marine life.
  • Cayo Guillermo Marina: A hub for water enthusiasts, Cayo Guillermo Marina provides opportunities for deep-sea fishing, boat rentals, and guided tours. The marina's friendly staff can help you arrange exciting excursions to nearby cays, ensuring an unforgettable experience on the water. Don't miss the chance to witness breathtaking sunsets over the marina.
  • Parque Natural el Bagá: This natural park is a treasure trove of biodiversity, showcasing Cuba's unique flora and fauna. Hiking through the park allows you to immerse yourself in nature, with opportunities to spot rare bird species and enjoy the lush landscapes. It’s a perfect escape for nature lovers and outdoor adventurers.
  • Cayo Coco Beach: Just a short trip away, Cayo Coco Beach boasts picturesque vistas and a lively atmosphere. It's an excellent place for beach activities, including volleyball and paddleboarding. The surrounding resorts offer dining options where you can savour local Cuban cuisine, making it a great spot to unwind after a day of exploration.

4 tips to find a great Cayo Guillermo hotel deal

  1. Book for the cheapest times: The most affordable time to visit Cayo Guillermo is between September and November, when hotel rates are significantly lower. If you're an international traveller, it's advisable to book your flight at least four months in advance to secure the best prices. For a great value for money experience, plan to stay for at least 3-4 days to fully explore the beautiful beaches and stunning natural scenery that Cayo Guillermo has to offer. This budget-friendly destination is perfect for those seeking a memorable getaway without breaking the bank.
  2. Look for last-minute deals on Hotels.com: If you're looking for spontaneous getaways, Cayo Guillermo offers enticing last-minute deals that could save you money on your next trip. To find these offers on Hotels.com, navigate to the DealsOpens in a new window or Last-Minute DealsOpens in a new window section, where you may discover attractive hotel rates as your travel date approaches. You could also enable email alerts or push notifications from Hotels.com to keep informed about flash sales and exclusive last-minute promotions, ensuring you won’t miss any chances to snag a great deal.
  3. Be flexible with dates: Prices may fluctuate due to various factors, including the hotel's location, star rating, and the time of year. Consequently, being flexible with your travel dates could increase the likelihood that you’ll save on hotel expenses in Cayo Guillermo.
  4. Consider your location: When booking your holiday accommodations on Hotels.com, it's important to consider your location. Staying closer to major attractions or city centres may offer added convenience, but it usually tends to come at a higher price. For more affordable options, consider looking for hotels in less central areas or neighbourhoods, finding a balance between cost and the accessibility of the sites you plan to visit.

Best time to go to Cayo Guillermo

Cayo Guillermo experiences its lowest average temperature in January, at 75.0°F (23.9°C), while August is the hottest month, with an average temperature of 83.8°F (28.8°C). October is typically the wettest month. If you’re looking to soak up the lively atmosphere in Cayo Guillermo, January, March, and April are the peak months to visit, bustling with fellow travelers. During this peak period, the weather is mostly sunny, accompanied by no to light rainfall. However, if you prefer a more relaxed experience, June, October, and November are perfect for a quieter getaway, marked by light to moderate rainfall and mostly sunny to mostly cloudy conditions.

If you're looking for a place to get away, look no further than Cayo Guillermo. Whether you're planning to stay for a night or for the week, the area around Cayo Guillermo has accommodations to fit every need. Search for hotels in Cayo Guillermo with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Cayo Guillermo hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Cayo Guillermo hotel deals are here with our lowest price guarantee.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com™ app users and Hotels.com™ Rewards members. Limited availability, blackout periods may apply.

Hotels.com Rewards members save more, as compared to non-members shopping on Hotels.com. Members 18+. Eligible properties only. Reward Night worth average daily rate of 10 stamps (excluding taxes/fees). Taxes/fees payable on reward night. Booking exclusions apply, see terms https://ca.hotels.com/lp/b/terms-of-service?pos=HCOM_CA&locale=en_CA.