Hotels in Greenville

your current months are January, 2025 and February, 2025.
January 2025
February 2025
Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Where to stay in Greenville?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Greenville

The region around Greenville is home to attractions such as Little White House and Franklin Delano Roosevelt State Park.

Frequently asked questions

Can I book a refundable hotel in Greenville?
If you want the flexibility to change your travel plans to Greenville, most accommodations provide refundable* rates you can book. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Where can I stay with my pet in Greenville?
Your animal companion is welcome at this pet-friendly hotel: Hunter’s Getaway.
Where can I stay if I'm visiting Greenville for a family-friendly vacation?
Parents traveling with children may want to consider Hunter’s Getaway.
What will the weather in Greenville be like during my vacation?
The warmest months in Greenville are usually July and August with an average temp of 77°F. January and February are the chilliest months when the average temp is 49°F. The rainiest months are December and August.
Why should I book my Greenville hotel through Hotels.com?
There are plenty of reasons to book your Greenville travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.