Hotels in Santee

Tue, Nov 18
Sat, Nov 22
November 2025
17
December 2025

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Nov 17 - Nov 18
Tomorrow
Nov 18 - Nov 19
This weekend
Nov 21 - Nov 23
Next weekend
Nov 28 - Nov 30

Where to stay in Santee?

CA $109
CA $121 total
includes taxes & fees
Nov 18 - Nov 19
Baymont by Wyndham Santee
CA $88
CA $98 total
includes taxes & fees
Nov 18 - Nov 19
Red Roof Inn Santee
CA $102
CA $113 total
includes taxes & fees
Nov 18 - Nov 19
Super 8 by Wyndham Santee
CA $166
CA $184 total
includes taxes & fees
Nov 23 - Nov 24
Best Western Plus Santee Inn
CA $159
CA $177 total
includes taxes & fees
Dec 7 - Dec 8
Hampton Inn Santee-I-95
CA $163
CA $181 total
includes taxes & fees
Dec 7 - Dec 8
Fairfield Inn & Suites by Marriott Santee
CA $150
CA $167 total
includes taxes & fees
Dec 4 - Dec 5
Comfort Inn & Suites Santee
CA $145
CA $161 total
includes taxes & fees
Dec 7 - Dec 8
Tru By Hilton Santee
CA $165
CA $184 total
includes taxes & fees
Dec 16 - Dec 17
Holiday Inn Santee by IHG
CA $88
CA $98 total
includes taxes & fees
Dec 4 - Dec 5
Econo Lodge
CA $84
CA $94 total
includes taxes & fees
Nov 18 - Nov 19
Travelodge by Wyndham Santee
CA $76
CA $92 total
includes taxes & fees
Nov 24 - Nov 25
Quality Inn & Suites
CA $98
CA $108 total
includes taxes & fees
Dec 3 - Dec 4
Ramada by Wyndham Santee I-95
Bells Marina & Resort
Peach Tree Inn
CA $68
CA $76 total
includes taxes & fees
Nov 23 - Nov 24
Starlight Stays
CA $118
CA $131 total
includes taxes & fees
Dec 2 - Dec 3
Fairfield Inn by Marriott Orangeburg
CA $100
CA $111 total
includes taxes & fees
Nov 18 - Nov 19
Best Inn of Manning
CA $107
CA $119 total
includes taxes & fees
Nov 18 - Nov 19
Travelodge by Wyndham Orangeburg
CA $181
CA $201 total
includes taxes & fees
Nov 19 - Nov 20
SpringHill Suites by Marriott Orangeburg
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Check out pet-friendly hotels in Santee

Fairfield Inn & Suites by Marriott Santee

Santee
CA $163
CA $181 total
includes taxes & fees
Dec 7 - Dec 8
Fairfield Inn & Suites by Marriott Santee

Tru By Hilton Santee

Santee
CA $145
CA $161 total
includes taxes & fees
Dec 7 - Dec 8
Tru By Hilton Santee

Hampton Inn Santee-I-95

Santee
CA $159
CA $177 total
includes taxes & fees
Dec 7 - Dec 8
Hampton Inn Santee-I-95

Baymont by Wyndham Santee

Santee
CA $109
CA $121 total
includes taxes & fees
Nov 18 - Nov 19
Baymont by Wyndham Santee

Holiday Inn Santee by IHG

Santee
CA $165
CA $184 total
includes taxes & fees
Dec 16 - Dec 17
Holiday Inn Santee by IHG

Best Western Plus Santee Inn

Santee
CA $166
CA $184 total
includes taxes & fees
Nov 23 - Nov 24
Best Western Plus Santee Inn

Red Roof Inn Santee

Santee
CA $88
CA $98 total
includes taxes & fees
Nov 18 - Nov 19
Red Roof Inn Santee

Travelodge by Wyndham Santee

Santee
CA $84
CA $94 total
includes taxes & fees
Nov 18 - Nov 19
Travelodge by Wyndham Santee

Super 8 by Wyndham Santee

Santee
CA $102
CA $113 total
includes taxes & fees
Nov 18 - Nov 19
Super 8 by Wyndham Santee

Econo Lodge

Santee
CA $88
CA $98 total
includes taxes & fees
Dec 4 - Dec 5
Econo Lodge
View all properties

You may also like hotels with pools in Santee

Fairfield Inn & Suites by Marriott Santee

Santee
CA $163
CA $181 total
includes taxes & fees
Dec 7 - Dec 8
Fairfield Inn & Suites by Marriott Santee

Hampton Inn Santee-I-95

Santee
CA $159
CA $177 total
includes taxes & fees
Dec 7 - Dec 8
Hampton Inn Santee-I-95

Tru By Hilton Santee

Santee
CA $145
CA $161 total
includes taxes & fees
Dec 7 - Dec 8
Tru By Hilton Santee

Holiday Inn Santee by IHG

Santee
CA $165
CA $184 total
includes taxes & fees
Dec 16 - Dec 17
Holiday Inn Santee by IHG

Comfort Inn & Suites Santee

Santee
CA $150
CA $167 total
includes taxes & fees
Dec 4 - Dec 5
Comfort Inn & Suites Santee

Best Western Plus Santee Inn

Santee
CA $166
CA $184 total
includes taxes & fees
Nov 23 - Nov 24
Best Western Plus Santee Inn

Super 8 by Wyndham Santee

Santee
CA $102
CA $113 total
includes taxes & fees
Nov 18 - Nov 19
Super 8 by Wyndham Santee

Ramada by Wyndham Santee I-95

Santee
CA $98
CA $108 total
includes taxes & fees
Dec 3 - Dec 4
Ramada by Wyndham Santee I-95

Quality Inn & Suites

Santee
CA $76
CA $92 total
includes taxes & fees
Nov 24 - Nov 25
Quality Inn & Suites
View all properties

You can also stay at family-friendly hotels in Santee

Fairfield Inn & Suites by Marriott Santee

Santee
CA $163
CA $181 total
includes taxes & fees
Dec 7 - Dec 8
Fairfield Inn & Suites by Marriott Santee

Comfort Inn & Suites Santee

Santee
CA $150
CA $167 total
includes taxes & fees
Dec 4 - Dec 5
Comfort Inn & Suites Santee

Best Western Plus Santee Inn

Santee
CA $166
CA $184 total
includes taxes & fees
Nov 23 - Nov 24
Best Western Plus Santee Inn

Travelodge by Wyndham Santee

Santee
CA $84
CA $94 total
includes taxes & fees
Nov 18 - Nov 19
Travelodge by Wyndham Santee

Econo Lodge

Santee
CA $88
CA $98 total
includes taxes & fees
Dec 4 - Dec 5
Econo Lodge
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Santee are cheapest in September
Price trends for hotels in Santee
Pricing is based on two traveller single night rates
View properties in November
Typical weather for Santee
November
High crowds
High 19°C / low 9°C. Sunny most days.
View properties in November
19°
15°
13°
16°
19°
24°
13°
28°
17°
31°
21°
33°
23°
32°
23°
29°
20°
24°
15°
Monthly weather averages (˚C)

Top landmarks in Santee

Santee State Park

4.0/5 (112 reviews)
Santee State Park is 2.7 mi (4.4 km) from central Santee, why not stop by during your stay.
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Santee Cooper Country Club

3.9/5 (47 reviews)
You might want to play some rounds at Santee Cooper Country Club, located 0.6 mi (1 km) from central Santee. If Santee Cooper Country Club doesn't quite scratch your golfing itch, Santee National Golf Club is also nearby.
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Santee National Golf Club

3.8/5 (43 reviews)
You might want to practice your swing at Santee National Golf Club, a golf course located 0.8 mi (1.4 km) from central Santee. If Santee National Golf Club doesn't quite scratch your golfing itch, Santee Cooper Country Club is also nearby.
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Santee Town Hall

Santee Town Hall is worth a visit, located 1 mi (1.6 km) from central Santee.
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Learn more about Santee

Notable for its golfing, Santee features attractions such as Santee Cooper Country Club and Santee National Golf Club. Visitors to this welcoming city speak highly of the restaurants whereas sights include Santee State Park and Lake Marion.

See all hotels in Santee
Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina

Check out reviews of Santee hotels guests love

Tru By Hilton Santee

Tru By Hilton Santee

10/10 Excellent
"I spilled some water on the bedroom floor and i cleaned it up. The paper towel showed how dirty the floor was. "
Tracey 1-night trip
Posted 2 days ago
Tru By Hilton Santee
Fairfield Inn & Suites by Marriott Santee

Fairfield Inn & Suites by Marriott Santee

10/10 Excellent
"Everything was great"
David 1-night trip
Posted 2 days ago
Fairfield Inn & Suites by Marriott Santee
Red Roof Inn Santee

Red Roof Inn Santee

10/10 Excellent
"It's a good stop for the price "
Martin 3-night trip
Posted 3 days ago
Red Roof Inn Santee
Comfort Inn & Suites Santee

Comfort Inn & Suites Santee

10/10 Excellent
"Everything was what we expected. "
Paul 1-night trip
Posted 4 days ago
Comfort Inn & Suites Santee
Hampton Inn Santee-I-95

Hampton Inn Santee-I-95

10/10 Excellent
"Clean room and friendly staff. "
Jon 1-night trip
Posted 7 days ago
Hampton Inn Santee-I-95
Baymont by Wyndham Santee

Baymont by Wyndham Santee

10/10 Excellent
"Room is very clean. Good for the prize. I recommend this place "
Lucie 1-night trip
Posted 8 days ago
Baymont by Wyndham Santee
Super 8 by Wyndham Santee

Super 8 by Wyndham Santee

10/10 Excellent
"Clean, easy to get on and off 95 north or south"
Detlev 1-night trip
Posted 10 days ago
Super 8 by Wyndham Santee
Holiday Inn Santee by IHG

Holiday Inn Santee by IHG

10/10 Excellent
"Very friendly staff. Easy location right off 95...Perfect. "
Rolf 1-night trip
Posted 11 days ago
Holiday Inn Santee by IHG
Best Western Plus Santee Inn

Best Western Plus Santee Inn

10/10 Excellent
"Room was nice and friendly staff!"
Craig 1-night trip
Posted 2 weeks ago
Best Western Plus Santee Inn

Frequently asked questions

Can I book refundable accommodations in Santee?
If you want the flexibility to change your plans to Santee, most accommodations provide refundable* rates you can book. You can see these properties by searching our site and using the "fully refundable" filter to narrow down the results.
Where can I stay in Santee if I want a vacation rental instead of a hotel?
Browse 9 vacation homes on our site. You also might want to book one of 95 condos for your trip.
What will the weather in Santee be like during my vacation?
July and August are typically the warmest months in Santee when the average temp is 79°F. January and February are the coldest months when the average temperature is 52°F. August and July are the months with the most rain.
Why should I book my Santee hotel with Hotels.com?
There are lots of reasons to book your Santee trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Santee

Embrace Serenity: Discover the Enchanting Lakes of Santee

Nestled in the heart of South Carolina, Santee is a hidden gem for nature lovers and outdoor enthusiasts. Renowned for its stunning Santee State Park, this charming destination offers breathtaking lake views, lush landscapes, and a plethora of recreational activities, from fishing and boating to hiking and birdwatching. The tranquil shores of Lake Marion invite relaxation and adventure alike, making it perfect for romantic getaways or family vacations. With its friendly small-town vibe and rich Southern hospitality, Santee promises memorable experiences amidst the beauty of nature, making it an ideal off-the-beaten-path retreat. For unmissable hotel rates in Santee, be sure to check out Hotels.com's Last-Minute DealsOpens in a new window on travel.

Discover great hotels in Santee

Santee, South Carolina offers a range of hotel accommodations to suit different budgets and preferences. From affordable options to comfortable mid-range hotels, visitors can find friendly stays amid scenic surroundings. Whether you’re seeking a relaxing escape or convenient access to local attractions, Santee has a variety of choices for your vacation. These are some of the hotels preferred by our travelers in Santee:

  1. Days Inn by Wyndham SummertonOpens in a new window: This inviting 2.0-star hotel is perfect for leisure travelers seeking a comfortable and pet-friendly getaway. Enjoy family-friendly amenities, including complimentary cribs, ensuring a relaxing stay for those travelling with young ones. The property’s warm atmosphere and welcoming policies create a distinctive experience, allowing guests to feel right at home while exploring the beautiful surroundings of Santee, South Carolina.
  2. Days Inn by Wyndham Orangeburg SouthOpens in a new window: Days Inn by Wyndham Orangeburg South is a cozy 2.0-star motel that caters to pet enthusiasts looking for a delightful escape. With its pet-friendly policies, this property allows for a seamless travel experience with furry companions. The motel’s relaxed atmosphere and convenient amenities make it an ideal choice for leisure travelers seeking comfort and accessibility during their stay in Santee. The welcoming environment enhances the overall enjoyment of your getaway.
  3. Palmetto InnOpens in a new window: Palmetto Inn is a charming 2.5-star motel designed for leisure travelers who appreciate a pet-friendly atmosphere. The property fosters a warm and inviting environment, perfect for those looking to explore Santee with their pets. Its convenient amenities and friendly policies create an enjoyable experience, ensuring guests can unwind and feel at ease throughout their stay. Immerse yourself in the unique charm of this lovely motel during your travels.

Top locations to stay in Santee

Some of the great areas to stay in Santee, South Carolina, are Summerton, Eutawville, and Holly Hill. Summerton offers excellent golf options, Eutawville is known for its scenic views and outdoor activities, while Holly Hill features charming local shops and eateries. For first-time visitors, Summerton is best suited due to its recreational amenities and welcoming atmosphere.

  1. SummertonOpens in a new window: Summerton is a charming spot for those who enjoy golf, with several scenic courses nearby that cater to all skill levels. The town's laid-back atmosphere makes it a perfect retreat for relaxation. Visitors can explore the quaint local shops and take in the natural beauty of Lake Marion, ideal for fishing and boating. Summerton also hosts various community events throughout the year, providing a glimpse into local culture. If you're looking for a peaceful getaway with outdoor activities and warm hospitality, Summerton is an excellent choice.
  2. EutawvilleOpens in a new window: Eutawville offers a unique slice of Southern charm, perfect for travelers who appreciate a slower pace of life. The town is located near Lake Marion, making it a great base for water activities like kayaking and fishing. Eutawville's friendly community and local festivals create a welcoming atmosphere. For those who enjoy history, the area features interesting sites that reflect the region's rich heritage. Enjoy a leisurely stroll through the picturesque streets and experience the warmth of small-town living.
  3. Holly HillOpens in a new window: Holly Hill is a delightful small town that showcases the best of rural South Carolina. Known for its natural beauty, the area is surrounded by lush landscapes and offers plenty of outdoor activities. While it may be quieter than other destinations, Holly Hill has a welcoming vibe and is perfect for those seeking a peaceful retreat. The local parks provide great picnic spots and opportunities for leisurely walks. It's an ideal place to unwind and enjoy the simple pleasures of life.

Things to do in Santee

Santee boasts stunning lakes surrounded by rolling hills and lush forests, offering a perfect backdrop for outdoor enthusiasts. Enjoy a day of golfing, cast a line for some fishing, or explore serene walking trails. With its blend of natural beauty and recreational activities, Santee promises an unforgettable escape.

  • Santee State ParkOpens in a new window – Discover the beauty of nature at Santee State Park, a national park that offers a variety of outdoor activities. You can hike along scenic trails that wind through lush forests or set up a picnic by the tranquil waters of the lake. Don't forget your fishing gear, as the park is known for excellent fishing spots. Whether you're hiking, bird-watching, or simply enjoying the peaceful surroundings, this park provides a perfect backdrop for a day in nature.
  • Taw Caw CreekOpens in a new window – Take a relaxing day at Taw Caw Creek, where you can enjoy the serene beauty of the lake. Whether you're kayaking, canoeing, or just soaking in the sun by the water's edge, it's an ideal spot for water lovers. The calm waters make it a great place for families to spend quality time together, with plenty of opportunities to spot local wildlife. Pack a lunch, grab your swim gear, and unwind in this picturesque setting.

4 tips for savvy savings when booking a hotel in Santee

  1. Book for the cheapest times: The most budget-friendly time to visit Santee is during January, February, and December, when hotel prices tend to be lower. For a great value for money experience, staying for at least 2 days is recommended to fully appreciate the city's key landmarks and cultural attractions. During your visit, you can enjoy local dining options, friendly cafes, and fresh seafood, as well as explore the beautiful lake for fishing or excursions. Santee offers a welcoming atmosphere and plenty of family-friendly activities, making it an ideal destination for those looking to make the most of their time without breaking the bank.
  2. Look for last-minute deals on Hotels.com: To explore last-minute deals for hotels in Santee, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window sections on Hotels.com, where you may discover discounted rates as your travel date approaches. Enabling email alerts or push notifications can keep you informed about flash sales and special promotions, enhancing your chances of securing cheap hotels in Santee. Additionally, Smart ShoppingOpens in a new window is a handy comparison tool available in the app that helps you compare hotel prices and amenities, ensuring that if prices drop or rooms become available, you're more likely to be the first to know for your spontaneous getaway.
  3. Be flexible with dates: Prices may fluctuate based on factors like the hotel's location, star rating, and the time of year, so being flexible with your travel dates could help you save on your stay at a Santee hotel. For those seeking unique accommodations, boutique hotels can provide a more personalized experience and potentially better value. When you book through Hotels.com, we’ll inform you whether the price for your chosen dates is above or below the average. If the price leans towards the higher end, we’ll suggest alternative dates that could help you secure a better deal.
  4. Consider your location: Hotels near the city centre usually tend to be more expensive, but with Santee's outstanding public transportation options, you may discover a more affordable independent hotel a bit farther out that’s still conveniently connected. For those interested in exploring alternative, less congested neighbourhoods or even lesser-known nearby cities, there is often great value for money to be found. Opting for these alternative destinations could provide a more authentic and budget-friendly experience.

Best time to go to Santee

Santee experiences its lowest average temperature in January, at 47.3°F (8.5°C), while July is the hottest month, with an average temperature of 81.5°F (27.5°C). August is usually the wettest month. March, April, and July are the peak travel months in Santee, attracting a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light rainfall. On the other hand, October to December tend to be quieter times to visit, marked by light rainfall and mostly sunny conditions.

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