Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveler experience. Last updated on .
Hotels in Seneca

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1. Tru by Hilton Seneca Clemson
Tru by Hilton Seneca ClemsonSeneca
9.2 out of 10, Wonderful, (902 reviews)
The price is CA $140
CA $154 total
includes taxes & fees
Dec 2 - Dec 3

2. Hampton Inn & Suites Seneca-Clemson Area
Hampton Inn & Suites Seneca-Clemson AreaSeneca
9.2 out of 10, Wonderful, (764 reviews)
The price is CA $175
CA $192 total
includes taxes & fees
Nov 29 - Nov 30

3. Fairfield Inn & Suites Seneca Clemson Univ Area
Fairfield Inn & Suites Seneca Clemson Univ AreaSeneca
9.2 out of 10, Wonderful, (289 reviews)
The price is CA $168
CA $184 total
includes taxes & fees
Nov 8 - Nov 9

4. Quality Inn Seneca US-123
Quality Inn Seneca US-123Seneca
8.0 out of 10, Very good, (766 reviews)
The price is CA $112
CA $132 total
includes taxes & fees
Dec 1 - Dec 2

5. Lakeside Lodge Clemson
Lakeside Lodge ClemsonSeneca
9.0 out of 10, Wonderful, (1,001 reviews)
The price is CA $152
CA $189 total
includes taxes & fees
Nov 2 - Nov 3

6. Best Western Seneca-Clemson
Best Western Seneca-ClemsonSeneca
8.4 out of 10, Very good, (698 reviews)
The price is CA $131
CA $144 total
includes taxes & fees
Dec 1 - Dec 2

7. Days Inn by Wyndham Seneca / Clemson Area
Days Inn by Wyndham Seneca / Clemson AreaSeneca
6.8 out of 10, Good, (792 reviews)
The price is CA $100
CA $110 total
includes taxes & fees
Dec 1 - Dec 2

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
9.8 out of 10, Exceptional, (117 reviews)
The price is CA $117
CA $191 total
includes taxes & fees
Nov 30 - Dec 1

9. The Abernathy of Clemson
The Abernathy of ClemsonClemson
9.6 out of 10, Exceptional, (657 reviews)
The price is CA $204
CA $227 total
includes taxes & fees
Nov 22 - Nov 23

10. Courtyard Marriott Clemson
Courtyard Marriott ClemsonClemson
9.0 out of 10, Wonderful, (592 reviews)
The price is CA $144
CA $160 total
includes taxes & fees
Nov 22 - Nov 23

11. Inn @ Clemson
Inn @ ClemsonClemson
8.0 out of 10, Very good, (1,000 reviews)
The price is CA $106
CA $118 total
includes taxes & fees
Nov 2 - Nov 3

12. Comfort Inn & Suites Clemson - University Area
Comfort Inn & Suites Clemson - University AreaClemson
8.4 out of 10, Very good, (1,002 reviews)
The price is CA $141
CA $157 total
includes taxes & fees
Nov 29 - Nov 30

13. Clemson University's James F. Martin Inn
Clemson University's James F. Martin InnClemson
9.4 out of 10, Exceptional, (1,001 reviews)
The price is CA $194
CA $216 total
includes taxes & fees
Nov 30 - Dec 1

14. Hampton Inn Clemson-University Area
Hampton Inn Clemson-University AreaClemson
8.8 out of 10, Excellent, (652 reviews)
The price is CA $153
CA $170 total
includes taxes & fees
Nov 8 - Nov 9

15. Holiday Inn Express & Suites Clemson by IHG
Holiday Inn Express & Suites Clemson by IHGClemson
8.8 out of 10, Excellent, (999 reviews)
The price is CA $180
CA $200 total
includes taxes & fees
Nov 8 - Nov 9

16. Best Western Plus Clemson Hotel & Conference Center
Best Western Plus Clemson Hotel & Conference CenterClemson
8.0 out of 10, Very good, (1,005 reviews)
The price is CA $141
CA $157 total
includes taxes & fees
Nov 30 - Dec 1

17. The Shepherd Hotel Downtown Clemson
The Shepherd Hotel Downtown ClemsonClemson
9.8 out of 10, Exceptional, (904 reviews)
The price is CA $292
CA $324 total
includes taxes & fees
Nov 2 - Nov 3

18. Econo Lodge Clemson - University Area
Econo Lodge Clemson - University AreaClemson
7.2 out of 10, Good, (160 reviews)
The price is CA $106
CA $119 total
includes taxes & fees
Nov 22 - Nov 23

19. Rodeway Inn & Suites Walhalla
Rodeway Inn & Suites WalhallaWalhalla
7.6 out of 10, Good, (199 reviews)
The price is CA $112
CA $124 total
includes taxes & fees
Nov 30 - Dec 1

20. The Inn at Patrick Square
The Inn at Patrick SquareClemson
9.8 out of 10, Exceptional, (935 reviews)
The price is CA $208
CA $231 total
includes taxes & fees
Nov 2 - Nov 3
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Showing deals for:Nov 1 - Nov 2

8.0 out of 10, Very good, (766 reviews)
The price is CA $131
per night
CA $154 total
includes taxes & fees
Showing deals for:Nov 2 - Nov 3

8.0 out of 10, Very good, (766 reviews)
The price is CA $131
per night
CA $154 total
includes taxes & fees
Showing deals for:Nov 6 - Nov 8

9.0 out of 10, Wonderful, (1,001 reviews)
The price is CA $166
per night
CA $410 total
includes taxes & fees
You may also like hotels with pools in Seneca

9.0 out of 10, Wonderful, (1001)
The price is CA $152
CA $189 total
includes taxes & fees
Nov 2 - Nov 3
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Seneca
Cottage
Family friendly
Top neighborhoods in Seneca

Downtown
Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

Serenity Bay
Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

Pine Ridge Point
Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.
Indian Oaks
Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.
Top landmarks in Seneca
Learn more about Seneca
Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

Check out reviews of Seneca hotels guests love

Lakeside Lodge Clemson
10/10 Excellent
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