Hotels in Seneca

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Tonight
Oct 11 - Oct 12
Tomorrow
Oct 12 - Oct 13
Next weekend
Oct 16 - Oct 18
In two weeks
Oct 23 - Oct 25

Where to stay in Seneca?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Seneca on Hotels.com. These Seneca hotels consistently deliver on quality, location and traveler experience. Last updated on .

A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

1. Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
CA $171
CA $188 total
includes taxes & fees
Oct 18 - Oct 19
Fairfield Inn & Suites Seneca Clemson Univ Area
A bathroom with a sink, mirror, towel rack, toilet, and a trash bin.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel dining area with a long table, multiple chairs, and a bar in the background.

2. Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
CA $176
CA $193 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Seneca-Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A food court with a beverage display, seating area, and a Clemson University sign.

3. Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
CA $152
CA $167 total
includes taxes & fees
Oct 18 - Oct 19
Tru by Hilton Seneca Clemson
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.

4. Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
CA $144
CA $159 total
includes taxes & fees
Oct 13 - Oct 14
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

5. Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
CA $155
CA $193 total
includes taxes & fees
Oct 12 - Oct 13
Lakeside Lodge Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

6. Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
CA $108
CA $127 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn Seneca US-123
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

7. Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
CA $121
CA $133 total
includes taxes & fees
Oct 13 - Oct 14
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.

8. Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
CA $132
CA $208 total
includes taxes & fees
Oct 20 - Oct 21
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A golf course with a water body, trees, and a distant view of a bridge.
An outdoor patio with tables and chairs, surrounded by trees and a view of a body of water.
A large, curved swimming pool with lounge chairs and umbrellas, surrounded by landscaped areas and a building in the background.
A modern building with a central entrance, surrounded by a well-maintained lawn and trees.

9. Clemson University's James F. Martin Inn

Clemson University's James F. Martin Inn
Clemson
CA $212
CA $236 total
includes taxes & fees
Oct 12 - Oct 13
Clemson University's James F. Martin Inn
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A modern living room with a sofa, two armchairs, a coffee table, and a potted plant.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.

10. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
CA $220
CA $245 total
includes taxes & fees
Oct 18 - Oct 19
The Abernathy of Clemson
A modern bar area with a menu board, bar stools, and a countertop with various items.
An outdoor patio with a circular fire pit surrounded by wicker furniture and a pergola overhead.
A modern lobby with a reception desk, a seating area with three chairs, a round table, and a bookshelf with books.
A modern dining area with a bar, bar stools, and a patterned rug.

11. Courtyard Marriott Clemson

Courtyard Marriott Clemson
Clemson
CA $159
CA $176 total
includes taxes & fees
Nov 1 - Nov 2
Courtyard Marriott Clemson
A reception area with a reception desk, a sofa, a staircase, and a wall with artwork.
A tiger mascot holding a sign with "HOWARD'S ROCK" text, a staircase, and a desk with a computer.
A hotel room with two beds, a desk, a television, and a clock on the wall.
A dining area with a brick floor, wooden tables, and chairs, a kitchen counter with appliances, and large windows offering a view of the outside.

12. Inn @ Clemson

Inn @ Clemson
Clemson
CA $106
CA $118 total
includes taxes & fees
Oct 12 - Oct 13
Inn @ Clemson
Room
A modern kitchen with a microwave, toaster, and coffee maker. There are white bowls and a coffee station.
A hotel hallway with a carpeted floor, light-colored walls, and doors on both sides.
A spacious room with a large window, a flat-screen TV mounted on the wall, and a seating area with sofas and chairs.

13. Comfort Inn & Suites Clemson - University Area

Comfort Inn & Suites Clemson - University Area
Clemson
CA $150
CA $167 total
includes taxes & fees
Nov 1 - Nov 2
Comfort Inn & Suites Clemson - University Area
A modern kitchen area with a bar counter and seating.
A modern living room with a grey sofa, purple and orange cushions, a coffee table with magazines, and a large window with patterned curtains.
A Hampton Inn with a modern design, featuring a prominent entrance and outdoor seating area.
A modern bar area with high stools and a poolside view.

14. Hampton Inn Clemson-University Area

Hampton Inn Clemson-University Area
Clemson
CA $156
CA $174 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn Clemson-University Area
A Holiday Inn Express hotel with a stone facade, large windows, and a parking lot.
A hotel breakfast area with a self-serve station, including a refrigerator, coffee machine, and fruit display.
A compact living space with a sofa, a desk, a television, and a kitchenette.
A hotel room with a large bed, a desk, a chair, a mirror, and a framed picture on the wall.

15. Holiday Inn Express & Suites Clemson by IHG

Holiday Inn Express & Suites Clemson by IHG
Clemson
CA $184
CA $204 total
includes taxes & fees
Oct 18 - Oct 19
Holiday Inn Express & Suites Clemson by IHG
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A modern bar area with a wooden ceiling, green bar stools, and a bar counter.
An outdoor patio with wicker furniture, a round table, and a fountain.

16. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
CA $277
CA $308 total
includes taxes & fees
Oct 31 - Nov 1
The Shepherd Hotel Downtown Clemson
A spacious indoor dining area with multiple tables and chairs, a food service counter, and a modern architectural design with balconies.
A spacious indoor area with multiple levels of balconies, seating areas, and a central open space.
A spacious indoor area with multiple seating arrangements, a ping pong table, and a bar area with purple accents.
A lobby with seating areas, a reception desk, and a patterned wall.

17. Best Western Plus Clemson Hotel & Conference Center

Best Western Plus Clemson Hotel & Conference Center
Clemson
CA $150
CA $167 total
includes taxes & fees
Oct 13 - Oct 14
Best Western Plus Clemson Hotel & Conference Center
A spacious hallway with a wooden ceiling, a sofa, a chair, and a lamp.
A modern restaurant with a marble-top dining table, blue upholstered chairs, and a variety of food items displayed in the background.
A hotel with a brick facade, multiple windows, and a sign reading "The Inn at Patrick Square".
A brick building with a sign reading "The Inn at Patrick Square".

18. The Inn at Patrick Square

The Inn at Patrick Square
Clemson
CA $212
CA $236 total
includes taxes & fees
Oct 14 - Oct 15
The Inn at Patrick Square
A kitchen with a coffee maker, microwave, and refrigerator.
A hotel room with a large bed, a bedside table, a nightstand, and a wall-mounted lamp.
A reception area with a check-in desk, a seating area with a bench, and a wall-mounted display of postcards.
A hotel room with a bed, a desk with a chair, a television, a small table, and a microwave.

19. Rodeway Inn & Suites Walhalla

Rodeway Inn & Suites Walhalla
Walhalla
CA $103
CA $115 total
includes taxes & fees
Nov 9 - Nov 10
Rodeway Inn & Suites Walhalla
A dining area with a table and chairs, large windows with a view of the outside, and a green sofa.
A reception desk with a vase of flowers, framed pictures, and a printer.
A hotel room with two beds, a desk, a chair, a TV, and a painting on the wall.
A gazebo with a tiled roof and a surrounding gravel area.

20. Days Inn by Wyndham Clemson

Days Inn by Wyndham Clemson
Clemson
CA $114
CA $127 total
includes taxes & fees
Oct 12 - Oct 13
Days Inn by Wyndham Clemson
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A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
CA $120
per night
CA $141 total
includes taxes & fees
Quality Inn Seneca US-123
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
CA $184
per night
CA $202 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A bathroom with a sink, mirror, towel rack, toilet, and a trash bin.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel dining area with a long table, multiple chairs, and a bar in the background.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
CA $191
per night
CA $210 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
CA $170
per night
CA $187 total
includes taxes & fees
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
CA $155
per night
CA $193 total
includes taxes & fees
Lakeside Lodge Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
CA $124
per night
CA $136 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A food court with a beverage display, seating area, and a Clemson University sign.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
CA $210
per night
CA $231 total
includes taxes & fees
Tru by Hilton Seneca Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
CA $170
per night
CA $249 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A bathroom with a sink, mirror, towel rack, toilet, and a trash bin.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel dining area with a long table, multiple chairs, and a bar in the background.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
CA $198
per night
CA $218 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
CA $198
per night
CA $218 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
CA $134
per night
CA $157 total
includes taxes & fees
Quality Inn Seneca US-123
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
CA $170
per night
CA $187 total
includes taxes & fees
Best Western Seneca-Clemson
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
CA $155
per night
CA $193 total
includes taxes & fees
Lakeside Lodge Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
CA $127
per night
CA $140 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area
An outdoor patio area with a fire pit, seating, and string lights.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A food court with a beverage display, seating area, and a Clemson University sign.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
CA $198
per night
CA $218 total
includes taxes & fees
Tru by Hilton Seneca Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
CA $170
per night
CA $249 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
CA $284
per night
CA $624 total
includes taxes & fees
Fairfield Inn & Suites Seneca Clemson Univ Area
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
CA $198
per night
CA $457 total
includes taxes & fees
Quality Inn Seneca US-123
A bathroom with a sink, mirror, towel rack, toilet, and a trash bin.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel dining area with a long table, multiple chairs, and a bar in the background.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
CA $408
per night
CA $897 total
includes taxes & fees
Hampton Inn & Suites Seneca-Clemson Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
CA $302
per night
CA $664 total
includes taxes & fees
Best Western Seneca-Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
CA $195
per night
CA $428 total
includes taxes & fees
Days Inn by Wyndham Seneca / Clemson Area
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
CA $130 off
CA $368
per night
CA $936 total
includes taxes & fees
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A clear lake with a rocky shoreline and a tree branch overhanging the water.
A grassy area with trees and a body of water.
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a dishwasher.
A two-story building with a garage, a staircase, and a view of the water.

6 Mi to South Cove Boat Ramp! Lake Keowee Escape

6 Mi to South Cove Boat Ramp! Lake Keowee Escape
Seneca
CA $307
per night
CA $1,004 total
includes taxes & fees
6 Mi to South Cove Boat Ramp! Lake Keowee Escape
An outdoor patio area with a fire pit, seating, and string lights.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A food court with a beverage display, seating area, and a Clemson University sign.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
CA $469
per night
CA $1,032 total
includes taxes & fees
Tru by Hilton Seneca Clemson
A covered deck with wooden beams, wicker furniture, and large windows overlooking a lake.
A covered outdoor deck with wooden beams, large windows, wicker furniture, and a swing.
A dining area with a wooden table set for four, surrounded by chairs. A fireplace is visible in the background, and there is a large window providing a view of the outdoors.
A single-story house with a covered porch, a driveway, and a view of the water.

Stunning Seneca Home w/ Lake Keowee Access!

Stunning Seneca Home w/ Lake Keowee Access!
Seneca
CA $678
per night
CA $1,913 total
includes taxes & fees
Stunning Seneca Home w/ Lake Keowee Access!
A wooden deck with a metal roof, overlooking a lake and houses.
A kitchen with a wooden table, white cabinets, a microwave, a coffee maker, and a sink.
A modern kitchen with a central island, a dining area with a wooden table and chairs, a grey sofa, and a ceiling fan.
A modern multi-story building with a wooden staircase leading up to a balcony, surrounded by trees.

Lake Keowee Gem! Close to Clemson & Hiking Trails

Lake Keowee Gem! Close to Clemson & Hiking Trails
Seneca
CA $731
per night
CA $1,982 total
includes taxes & fees
Lake Keowee Gem! Close to Clemson & Hiking Trails
A covered patio with wooden chairs and a table, overlooking a fenced yard with a body of water and trees.
A spacious living area with a sofa set, a glass coffee table, and a ceiling fan.
A two-story house with a dark roof, a garage, and a large rock in the foreground.
A modern kitchen with white cabinets, a stainless steel refrigerator, a microwave, a stove, and a dishwasher.

Lakefront Seneca Vacation Rental w/ Shared Dock!

Lakefront Seneca Vacation Rental w/ Shared Dock!
Seneca
CA $563
per night
CA $1,527 total
includes taxes & fees
Lakefront Seneca Vacation Rental w/ Shared Dock!

Check out pet-friendly hotels in Seneca

A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
CA $108
CA $127 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn Seneca US-123
An outdoor patio area with a fire pit, seating, and string lights.
A modern hotel with a prominent 'tru by Hilton' sign, a well-lit entrance, and a parking area.
A modern restaurant with a central counter, seating area, and a TV displaying news.
A food court with a beverage display, seating area, and a Clemson University sign.

Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson
Seneca
CA $152
CA $167 total
includes taxes & fees
Oct 18 - Oct 19
Tru by Hilton Seneca Clemson
A cabin with a cozy interior, a wooden exterior, and a view of the forest.
A cabin in a forest with a small deck and outdoor seating area.
A wooden interior with a table, chair, and a hanging lantern.
A wooden cabin bedroom with a bed, a desk, and a window overlooking a forest.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Seneca
CA $132
CA $208 total
includes taxes & fees
Oct 20 - Oct 21
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
CA $155
CA $193 total
includes taxes & fees
Oct 12 - Oct 13
Lakeside Lodge Clemson
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
CA $121
CA $133 total
includes taxes & fees
Oct 13 - Oct 14
Days Inn by Wyndham Seneca / Clemson Area
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You can also stay at hotels with a pool in Seneca

A multi-story hotel with a swimming pool, landscaped grounds, and a parking area.
A spacious dining area with a long wooden table and patterned upholstered chairs.
A spacious lobby with a stone fireplace, modern lighting fixtures, and a seating area with sofas and a coffee table.
A swimming pool with lounge chairs and a covered patio area, surrounded by trees and a view of a lake.

Lakeside Lodge Clemson

Lakeside Lodge Clemson
Seneca
CA $155
CA $193 total
includes taxes & fees
Oct 12 - Oct 13
Lakeside Lodge Clemson
A poolside area with outdoor seating and a view of a lake and forested hills.
A modern lobby with a reception desk, seating area, and a vending machine.
A modern lounge area with a round table, two green armchairs, a sofa, and a TV mounted on the wall.
A deck with outdoor seating overlooking a body of water, adjacent to a building with multiple windows.

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area
Seneca
CA $171
CA $188 total
includes taxes & fees
Oct 18 - Oct 19
Fairfield Inn & Suites Seneca Clemson Univ Area
A bathroom with a sink, mirror, towel rack, toilet, and a trash bin.
A reception area with a counter, chairs, and a patterned rug.
A long, narrow hallway with white walls and a light-colored floor, leading to a door at the end.
A hotel dining area with a long table, multiple chairs, and a bar in the background.

Hampton Inn & Suites Seneca-Clemson Area

Hampton Inn & Suites Seneca-Clemson Area
Seneca
CA $176
CA $193 total
includes taxes & fees
Oct 18 - Oct 19
Hampton Inn & Suites Seneca-Clemson Area
A hotel room with a bed, a desk, a chair, a large window with curtains, a bathroom with a bathtub, and a flat-screen TV.
A breakfast bar with waffle makers, coffee machines, and a clock on the wall.
A rectangular swimming pool with a metal ladder, surrounded by lounge chairs and tables, with a wooded area in the background.
A reception area with a brick wall, a reception desk, and a glass door leading outside.

Best Western Seneca-Clemson

Best Western Seneca-Clemson
Seneca
CA $144
CA $159 total
includes taxes & fees
Oct 13 - Oct 14
Best Western Seneca-Clemson
A restaurant interior with a counter, seating area, and a TV mounted on the wall.
A multi-story motel with a central entrance, a flag, and a parking lot with several cars.
A hotel room with a bed, desk, TV, and a bathroom visible through an open door.
A hotel room with a TV on a wooden cabinet, a desk with a lamp, a framed picture, and a chair.

Quality Inn Seneca US-123

Quality Inn Seneca US-123
Seneca
CA $108
CA $127 total
includes taxes & fees
Oct 18 - Oct 19
Quality Inn Seneca US-123
A modern dining area with a high ceiling, large windows, and a buffet setup.
A Days Inn reception area with a view of the parking lot and trees.
A swimming pool with lounge chairs and a fence, surrounded by trees.
A modern hotel lobby with a high ceiling, comfortable seating, large windows, and a view of the parking lot.

Days Inn by Wyndham Seneca / Clemson Area

Days Inn by Wyndham Seneca / Clemson Area
Seneca
CA $121
CA $133 total
includes taxes & fees
Oct 13 - Oct 14
Days Inn by Wyndham Seneca / Clemson Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Our prices for hotels in Seneca are cheapest in December
Price trends for hotels in Seneca
Pricing is based on two traveller single night rates
View properties in October
Typical weather for Seneca
October
High 23°C / low 12°C. Sunny most days.
View properties in October
23°
12°
17°
6°
12°
4°
10°
1°
13°
3°
17°
6°
22°
10°
26°
15°
31°
19°
32°
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31°
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Monthly weather averages (˚C)

Top neighborhoods in Seneca

A lakeside scene with autumn foliage, a clear sky, and a sunset.
A large lake surrounded by dense forests.

Downtown

Downtown Seneca charms visitors with well-preserved historical buildings that tell the story of its railroad heritage. The tree-lined Ram Cat Alley showcases local history through colourful murals, while the old courthouse square hosts seasonal farmers markets and community events. You can explore the Bertha Lee Strickland Cultural Museum or browse antique shops filled with Southern treasures. Family-owned cafes serve up delicious Southern comfort food like fried green tomatoes and barbecue. Accommodations range from historic bed & breakfasts in Victorian homes to budget-friendly motels. The entire downtown is walkable with wide sidewalks, making it easy to discover this authentic slice of small-town America at your own pace.

A sunset over a lake surrounded by dense forests and residential areas.

Serenity Bay

Lake Keowee beckons from this peaceful coastal retreat nestled in Saxony Forest. Serenity Bay lives up to its name with tree-lined streets perfect for contemplative walks. Nearby Keowee Key Golf Course offers tee times for enthusiasts, while South Beach provides sandy relaxation without the crowds. The natural setting creates an ideal escape for bird watchers and nature photographers. Vacation rentals with weathered wood siding and muted earth tones blend seamlessly into the forest canopy. Getting around requires your own wheels since public transit is limited. The area trades bustling nightlife for cricket choruses and ocean breezes filtering through pine trees—exactly what makes this hidden gem worth finding.

A sunset over a calm lake with a kayaker and a large tree on the shore.

Pine Ridge Point

Lake Keowee sparkles as the crown jewel of Pine Ridge Point, a peaceful residential haven in Seneca. Waterfront vacation homes nestle among tall pines, offering private docks and stunning views. Visitors spend days swimming in crystal-clear waters, boating across the lake, or simply unwinding on expansive decks beneath Carolina blue skies. This area is all about authentic lakeside living without commercial distractions. Most travellers cook in well-equipped rental kitchens or drive 15 minutes to Seneca for restaurants. Personal vehicles are essential for getting around, though scenic paths along the shoreline make for perfect evening strolls.

Indian Oaks

Indian Oaks gives you all the peaceful vibes of suburban life with none of the tourist chaos. This leafy area in Seneca lets you live like a local under a canopy of mature oak trees. The curved streets and manicured lawns create a park-like setting that's perfect for morning walks. Lake Keowee is just a short drive away when you need a water fix. You'll need wheels to get around since public transit is limited and restaurants aren't within walking distance. Most visitors stay in vacation rental homes with private yards and driveways. The area gets incredibly quiet after dark—ideal for travellers who want to experience authentic suburban living while having Seneca's attractions nearby.

Top landmarks in Seneca

A grassy field with yellow flowers and trees in the foreground, with mountains in the background.

Blue Ridge Field

Blue Ridge Field is worth a visit, located 0.8 mi (1.2 km) from central Seneca.
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A waterfall surrounded by autumn foliage.

High Falls County Park

High Falls County Park is worth a visit, located 7.8 mi (12.5 km) from central Seneca.
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Highpointe Field

Highpointe Field is worth a visit, located 5.6 mi (8.9 km) from central Seneca.
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Friendship Recreation Area

Friendship Recreation Area is worth a visit, located 6.5 mi (10.5 km) from central Seneca.
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South Cove Park

South Cove Park is worth a visit, located 2 mi (3.3 km) from central Seneca.
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Toy Train Park

Toy Train Park is worth a pic or two when discovering Downtown.
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World of Energy

If museums are on your list of things to see in Seneca, then you might want to head to World of Energy. If you want to experience more of the culture Seneca has to offer, head to Lake Keowee, Keowee Key Golf Course, and High Falls County Park.
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Oconee County Library Seneca Branch

Oconee County Library Seneca Branch is worth a pic or two when discovering Downtown.
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Learn more about Seneca

Between the crystal waters of Lake Keowee and the misty cascade of Isaqueena Falls lies a playground for outdoor enthusiasts. Kayak across the lake while keeping an eye out for bald eagles soaring overhead and blue herons stalking the shallows. The lush forests of Oconee State Park offer hiking trails for every skill level, with shade-dappled paths winding through ancient trees. Twin Lakes Recreation Area provides family-friendly spots to picnic after a morning on the water. Dog owners shouldn't miss The Pier Dog Park, where four-legged friends can splash along the shoreline. After a day of adventure, the coffeehouses in the historic downtown offer the perfect place to recharge while planning tomorrow's excursion to Keowee Key Golf Course or Lake Hartwell.

See all hotels in Seneca
A sunset over a lake surrounded by dense forests and residential areas.

Check out reviews of Seneca hotels guests love

Fairfield Inn & Suites Seneca Clemson Univ Area

Fairfield Inn & Suites Seneca Clemson Univ Area

8/10 Good
"We honestly didn't get to stay due to weather, but the hotel was clean and the staff that we interacted with were hospitable. The hotel was conveniently located and easy to find. I would stay there again."
Kim 1-night trip
Posted 15 hours ago
Fairfield Inn & Suites Seneca Clemson Univ Area
Tru by Hilton Seneca Clemson

Tru by Hilton Seneca Clemson

10/10 Excellent
"Everything was clean and just what we needed"
irene 1-night trip
Posted 2 days ago
Tru by Hilton Seneca Clemson
Best Western Seneca-Clemson

Best Western Seneca-Clemson

8/10 Good
"Stayed @ hotel for a football weekend. Hotel was awesome...one of the cleanest I've ever stayed in regardless of hotels' star ratings. The only reason I gave it 4 stars was two things....#1 The bed was a bit too hard for me. I'm used to softer mattresses, but these were a little too hard for me. #2....There was one staff person that was just not very friendly @ the front desk for part of my stay. She wasn't rude & she fulfilled my requests, but she just was not as outgoing as other team members & that stuck out to me. Would I stay at this hotel again? Absolutely...it's been many yrs since I've stayed in a BW...I tend to stay in the upper crust hotels, so I was very pleasantly surprised! Great job Best Western!!"
Susan 2-night trip
Posted 9 days ago
Best Western Seneca-Clemson

Frequently asked questions

How much does a hotel room cost in Seneca?
You can find top hotels in Seneca from CA $115 with options to suit your budget and needs. If you're after an affordable hotel in Seneca that meets all of your requirements, set your filters and then sort the results by "Price: low to high".
How can I find deals and earn rewards at Seneca hotels?
Discover great deals on Seneca hotel stays with Hotels.com. You can also look at hotel prices mid-week or during the low season to find off-peak deals. And make sure to check out our last-minute deals on Seneca hotels.
Can I book Seneca hotels with free cancellation?
It's easy to book a refundable Seneca hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". Most hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.
What are some of the best Seneca hotels with free parking?
If you're exploring by car, finding a great Seneca hotel with free parking is a win. Our travelers' favorites include:
Can I book refundable accommodations in Seneca?
If you want the flexibility to change your travel plans to Seneca, most accommodations offer refundable* bookable rates. You can find these properties by searching our site and using the "fully refundable" filter to narrow the results down.
Where can I stay in Seneca if I want a vacation rental instead of a hotel?
If you want to find a good alternative to a hotel, review our selection of 217 vacation homes. In addition, there are 24 apartments and 13 condos.
What will the weather in Seneca be like during my visit?
The warmest months in Seneca are usually July and August with an average temp of 76°F. January and February are the chilliest months when the average temp is 46°F. The rainiest months are December and January.
Why should I book my Seneca hotel with Hotels.com?
There are plenty of reasons to book your Seneca travel with us: our free cancellations on selected hotels gives you the flexibility you're looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Seneca

Discover Seneca: Where Nature's Majesty Meets Historic Charm

Seneca, South Carolina, is a charming city nestled in the heart of the Clemson area, offering a delightful blend of natural beauty and rich history. Explore the serene shores of Lake Hartwell, perfect for boating and fishing, or wander through the picturesque landscapes of nearby national parks. History enthusiasts will appreciate the historic college campus and the iconic sports stadium, which echo the area’s vibrant spirit. With its warm hospitality and captivating scenery, Seneca is an inviting getaway for those seeking adventure or a peaceful retreat. Experience the charm of this off-the-beaten-path destination! For great hotel rates in Seneca, be sure to check out Hotels.com's Last-Minute DealsOpens in a new window on travel.

Discover great hotels near Seneca

Seneca, South Carolina offers a range of hotel accommodations, from budget-friendly options to more upscale stays. You can expect comfortable rooms and various amenities to enhance your visit. Room rates typically vary based on the season, but you’ll find good value, making it an inviting destination for travelers. Here are some of the most popular hotels with our travelers near Seneca:

  1. Hampton Inn Clemson-University AreaOpens in a new window: Hampton Inn Clemson-University Area is a budget-friendly lodging option with a guest rating of 8.8. This hotel provides a welcoming atmosphere for LGBTQIA travelers and is perfect for those seeking a comfortable stay. Key amenities include a delightful breakfast, clean rooms, and courteous staff, ensuring a pleasant experience. The property features a relaxed environment ideal for those looking for a cozy and affordable getaway, making it an excellent choice for leisure travelers who appreciate value and comfort.
  2. The Abernathy of ClemsonOpens in a new window: With a stellar guest rating of 9.6, The Abernathy of Clemson is a 3.5-star hotel that shines for business travelers. This property boasts a prime location near the college, offering convenient access for visitors. Guests can enjoy spacious rooms, free parking, and a friendly atmosphere. The welcoming staff and great amenities enhance the overall experience, making it an ideal choice for those wanting to blend comfort with convenience during their stay.
  3. Clemson University's James F. Martin InnOpens in a new window: Clemson University's James F. Martin Inn is a 3.0-star hotel with an impressive guest rating of 9.4, catering primarily to leisure travelers with an interest in golf. This property features a delightful suite accommodating larger groups, enhancing the overall experience. While not centrally located to downtown, the hotel provides a unique golf-themed stay that resonates with sports enthusiasts. Its inviting ambiance makes it a preferred choice for those seeking a distinctive getaway in a serene setting.

Where to stay near Seneca

Some of the best areas to stay near Seneca, South Carolina, are Clemson, Pendleton, and Central. Clemson offers vibrant sports culture and beautiful gardens, Pendleton is rich in history and wildlife, while Central is family-friendly with access to nature. For first-time visitors, Clemson is the most appealing choice, with its lively atmosphere and diverse attractions.

  1. ClemsonOpens in a new window: Clemson is a vibrant spot that offers a mix of sports and culture, perfect for those wanting to experience the local spirit. Known for its passionate football scene, you can catch a game at Memorial Stadium, where the atmosphere is electric on game days. Nature lovers will appreciate the stunning South Carolina Botanical Gardens, a beautiful place to wander and relax. Lake Keowee is another must-see, providing opportunities for outdoor activities like boating and picnicking. With its lively cultural scene, Clemson is a fantastic choice for travelers looking to enjoy live music and engaging events in a charming community.
  2. PendletonOpens in a new window: Pendleton is a quaint town that’s perfect for those seeking a peaceful getaway steeped in history and nature. The area is known for its beautiful landscapes and wildlife, making it a great spot for horseback riding and outdoor exploration. You can visit local museums to get a glimpse of the area’s rich heritage, or simply enjoy a leisurely stroll through its historic streets. Pendleton's friendly atmosphere and slower pace provide a lovely contrast to busier destinations, making it ideal for travelers looking to unwind and connect with nature.
  3. CentralOpens in a new window: Central is a small, family-friendly town that offers a warm community vibe and plenty of sunny weather. It's a great base for enjoying the outdoors, with beautiful forests and scenic sunsets that provide a perfect backdrop for relaxation. Families can engage in various sports and nature activities, making it a delightful spot for all ages. Whether you’re exploring the nearby trails or enjoying a picnic, Central provides a charming retreat that emphasizes togetherness and the joys of nature.

Things to do in Seneca

Seneca beckons with its stunning lakeside views, lush parks, and nearby mountains, making it a perfect playground for outdoor enthusiasts. Enjoy thrilling sports activities, from boating on serene waters to hiking scenic trails. With a vibrant university atmosphere, there's always something happening, ensuring an unforgettable visit.

  • WoodburnOpens in a new window – Step back in time at this historic house, where you can appreciate beautiful architecture and learn about the rich history of the region. The surrounding grounds are perfect for a leisurely walk, so take a moment to enjoy the lush scenery and tranquil atmosphere.
  • Memorial StadiumOpens in a new window – Experience the excitement at this historic sports stadium, where you can catch a thrilling game or event. The vibrant energy of the crowd and the impressive facilities make it a must-visit for sports enthusiasts looking to soak in the local passion for athletics.
  • Larry W. Abernathy Waterfront ParkOpens in a new window – Unwind at this urban park situated along the water, ideal for a relaxing stroll or a picnic with family and friends. Enjoy the scenic views of the lake while taking advantage of the park's various recreational facilities.
  • Fort HillOpens in a new window – Explore this historic house, notable for its connection to significant local figures and events. The architecture offers a glimpse into the past, while the surrounding grounds provide a peaceful setting for reflection and relaxation.
  • Stumphouse Mountain TunnelOpens in a new window – Venture into this historic site, where you can walk through the intriguing tunnel and learn about its fascinating history. The surrounding area features beautiful landscapes, making it a great spot for outdoor enthusiasts to explore.

4 tips for savvy savings when booking a hotel in Seneca

  1. Book for the cheapest times: The most affordable time to visit Seneca is during January, February, and December, when hotel prices are typically lower. For those looking to really experience the key historical and cultural landmarks, a stay of at least 2 to 3 days is recommended. This duration allows visitors to explore various attractions, including the local university, scenic lakes, and family-friendly spots. With friendly people and plenty of opportunities for boating and enjoying the outdoors, Seneca offers great value for money, making it an excellent choice for those on a budget. It's worth noting that prices may drop during these off-peak months, enhancing the overall experience for visitors.
  2. Look for last-minute deals on Hotels.com: To discover last-minute deals to Seneca, visit the DealsOpens in a new window or Last-Minute DealsOpens in a new window sections on Hotels.com, where you may find discounted hotel rates as your travel date approaches. Enabling email alerts or push notifications from Hotels.com could help you stay updated on flash sales and special promotions, ensuring you don't miss potential savings. Additionally, Smart ShoppingOpens in a new window is a comparison tool available in the app that allows you to compare hotel prices and amenities easily. By keeping an eye on your favourite hotels, you could be among the first to know if prices drop or availability changes, making it easier to plan a spontaneous getaway.
  3. Be flexible with dates: Prices may fluctuate based on factors such as the hotel's location, star rating, and the time of year, so being flexible with your travel dates could help you find a more favourable rate for your stay in a Seneca hotel. For those in search of unique accommodations, boutique hotels can provide a more personalized experience and possibly better value. When you book with Hotels.com, we'll inform you if the price for your chosen dates is above or below the average. If the price is on the higher end, we may suggest alternative dates that could help you find a more attractive rate.
  4. Consider your location: Hotels located near the city centre usually tend to be more expensive, but with Seneca's outstanding public transportation options, you might discover a more affordable independent hotel a bit further out that still has good connectivity. For those interested in exploring alternative, less crowded neighbourhoods or even lesser-known nearby cities, there is often excellent value for money to be found. Opting for these alternative destinations could provide a more authentic and budget-friendly experience.

Best time to go to Seneca

Seneca experiences its lowest average temperature in January, at 41.7°F (5.4°C), while July is the hottest month, with an average temperature of 79.2°F (26.2°C). December is usually the wettest month. June, July, and September are the peak travel months in Seneca, attracting a higher number of tourists. During this peak period, the weather is mostly sunny, accompanied by light rainfall. On the other hand, October to December tend to be quieter times to visit, marked by light rainfall and mostly sunny conditions.

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