Hotels in Defiance

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Where to stay in Defiance?

Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Defiance on Hotels.com. These Defiance hotels consistently deliver on quality, location and traveler experience. Last updated on September 23, 2026.

A hotel room with two beds, a desk with a chair, a television, and a window with curtains.

A reception desk with a modern design, featuring a blue geometric wall and a wooden finish.

A Holiday Inn Express hotel with a brick facade, a covered entrance, and a clear sky.

A hotel lobby with a seating area, a reception desk, and a flat-screen TV mounted on the wall.

1. Holiday Inn Express St. Louis West - O'Fallon by IHG

O'Fallon

CA $134

CA $158 total

includes taxes & fees

Oct 22 - Oct 23

A hotel room with a bed, a sofa, a coffee table, and wall art.

A hotel lobby with a reception desk, seating area, and a large potted plant.

A Sleep Inn & Suites hotel with a modern brick facade, a covered entrance, and a parking lot.

An indoor swimming pool with a clear view of the outside, a metal ladder, and a ceiling with recessed lighting.

2. Sleep Inn & Suites O'Fallon MO - Technology Drive

O'Fallon

CA $116

CA $137 total

includes taxes & fees

Oct 13 - Oct 14

A hotel with a prominent tower, a fountain in the courtyard, and a well-maintained garden.

A hotel room with a large bed, a bedside lamp, a telephone, a mirror, and a bathroom with a sink and towel rack.

A spacious living area with a staircase, a large painting, and a chandelier.

A modern bathroom with a large mirror, white vanity, and a bathtub.

3. The Wildwood Hotel

Wildwood

CA $128

CA $149 total

includes taxes & fees

Oct 21 - Oct 22

A hotel room with two beds, a desk, a chair, a TV, and a large window.

A brick building with a sign reading "Comfort Inn & Suites."

A modern hotel room with a sofa, a small table, a yellow ottoman, a wooden desk, a flat-screen TV, and a bathtub.

A spacious lobby with a blue sofa set, a reception desk, and a modern chandelier.

4. Comfort Inn & Suites Chesterfield - St. Louis

Chesterfield

CA $113

CA $137 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with a stone fire pit, wicker furniture, and a covered seating area with a view of the building's interior.

A multi-story hotel with a brick facade, a covered outdoor seating area with a fire feature, and a sign indicating it is a Marriott property.

A hotel room with a sofa, a side table, a lamp, a flat-screen TV, and a bed with a red blanket.

A hotel room with a large bed, bedside lamps, a TV, a desk, and a bathroom.

5. TownePlace Suites by Marriott St. Louis Chesterfield

Chesterfield

CA $180

CA $211 total

includes taxes & fees

Oct 5 - Oct 6

A spacious lobby with a high ceiling, a central seating area with sofas and a coffee table, and a large window providing natural light.

A hotel with a covered entrance, multiple flags, and a well-maintained lawn.

A shop with a variety of snacks and beverages, including a refrigerated section with drinks and a display of packaged snacks.

A spacious lobby with a sofa, a coffee station, and a reception desk.

6. Hilton Garden Inn St. Louis/O'Fallon MO

O'Fallon

CA $152

CA $180 total

includes taxes & fees

Oct 11 - Oct 12

A multi-story hotel with a central entrance featuring a covered patio area.

A hotel with a swimming pool, outdoor seating, and a covered patio area.

A hotel room with a sofa, armchair, bedside table, lamp, TV, and a bed with patterned bedding.

A hotel lobby with a sectional sofa, a fireplace, a flat-screen TV, and framed artwork on the walls.

7. Staybridge Suites O'Fallon Chesterfield by IHG

O'Fallon

CA $156

CA $184 total

includes taxes & fees

Oct 4 - Oct 5

A spacious living room with a large painting, a fireplace, a staircase, and modern furniture.

A hotel room with a dining area, a fireplace, and a view of the outdoors.

A swimming pool with tiled edges and a hot tub area, surrounded by windows and chairs.

A hotel room with a large bed, two sofas, a desk, and a TV.

8. Best Western Plus Washington Hotel

Washington

CA $181

CA $206 total

includes taxes & fees

Sep 27 - Sep 28

A spacious lobby with a high ceiling, a dining area, and a kitchen in the background.

A modern hotel lobby with a computer desk, a flat-screen TV, and a ceiling fan.

A hotel room with a bathroom, a bed, a nightstand, and a window.

An indoor swimming pool with stone flooring, white walls, and a green stripe. There are chairs and a door with a sign.

9. Quality Inn Near Six Flags St. Louis

Pacific

CA $139

CA $159 total

includes taxes & fees

Sep 24 - Sep 25

Two people in a swimming pool with colorful inflatable rings.

A spacious lobby with a stone fireplace, a chandelier, and a staircase.

A lobby with a grand staircase, two patterned sofas, a glass coffee table, and a large mirror.

A hotel room with a large bed, a desk, a TV, and a view of a pool through the glass door.

10. Holiday Inn St. Louis West Six Flags by IHG

Eureka

CA $147

CA $172 total

includes taxes & fees

Sep 29 - Sep 30

A modern kitchen area with a breakfast bar, a coffee machine, and a refrigerator displaying menu options.

A pool area with a blue pool lift chair, a pool user capacity sign, and a tiled wall.

A Holiday Inn Express & Suites building with a brick facade, a covered entrance, and a numbered address.

A hotel room with two beds, a blue sofa, a small table, and a kitchenette.

11. Holiday Inn Express & Suites St. Louis - Chesterfield by IHG

Chesterfield

CA $160

CA $187 total

includes taxes & fees

Oct 4 - Oct 5

An outdoor patio area with wicker furniture and a central fire feature.

A hotel room with a bed, a sofa, a desk, and a chair.

A modern hotel lobby with a reception desk, seating area, and a television screen displaying a map.

A Courtyard Marriott hotel with a parking lot and a green shuttle service.

12. Courtyard by Marriott St. Louis Chesterfield

Chesterfield

CA $170

CA $197 total

includes taxes & fees

Oct 11 - Oct 12

A spacious lobby with a stone fireplace, seating area, and a bar with high stools.

A hotel lobby with a seating area featuring two armchairs, a round coffee table, and a flat-screen TV mounted on a wooden wall.

A hotel pantry stocked with beverages and snacks, a refrigerated display case, and a sign reading "The Market".

A multi-story hotel with a central entrance, large windows, and a well-maintained lawn.

13. Residence Inn by Marriott O'Fallon

O'Fallon

CA $184

CA $217 total

includes taxes & fees

Oct 11 - Oct 12

An indoor swimming pool with a hot tub, clear signage, and a view of the outside through large windows.

A spacious living area with a blue wall, yellow armchairs, a blue sofa, and a wooden coffee table.

A hotel room with two beds, a desk with a TV, a chair, and a lamp.

A modern dining area with yellow and blue chairs, a flat-screen TV, and a kitchen area with appliances.

14. Comfort Inn Near Six Flags St. Louis

Pacific

CA $139

CA $159 total

includes taxes & fees

Oct 19 - Oct 20

A courtyard with a central seating area, surrounded by trees and a building with a pitched roof.

A modern dining area with a long table, multiple chairs, and pendant lighting.

A store interior with a 'Treats' sign, snack shelves, and a chalkboard with a welcome message.

A modern hotel room with a large window, a desk with a flat-screen TV, a comfortable seating area, and a decorative wall piece.

15. Hampton Inn & Suites St. Louis/Chesterfield

Chesterfield

CA $173

CA $202 total

includes taxes & fees

Sep 27 - Sep 28

A Super 8 hotel with a flat facade, multiple windows, and a parking lot.

A bathroom with a shower, a small white stool, and a towel rack.

A hotel room with a bed, a desk, a chair, a nightstand, a lamp, and a large cityscape artwork on the wall.

A hotel room with a flat-screen TV, a wooden dresser, a beige sofa, a teal carpet, and a window with curtains.

16. Super 8 by Wyndham Eureka/Six Flags Nearby

Eureka

CA $94

CA $110 total

includes taxes & fees

Oct 8 - Oct 9

A modern kitchen with stainless steel appliances, a central island with stools, and a wine cooler.

A spacious living area with a fireplace, a television mounted above it, and a comfortable seating arrangement.

A spacious lobby with a seating area, a reception desk, and a kitchen area.

A Hilton Garden Inn with a brick facade, a covered entrance, and landscaped gardens.

17. Hilton Garden Inn Chesterfield

Chesterfield

CA $148

CA $172 total

includes taxes & fees

Oct 4 - Oct 5

A modern living room with a stone fireplace, a large window, and a seating area with a coffee table.

A Fairfield Inn & Suites hotel with a modern design, featuring a covered entrance, multiple floors, and a parking lot.

An outdoor patio with tables and chairs, umbrellas, and a brick building in the background.

An indoor swimming pool with clear glass walls, lounge chairs, and a tiled deck.

18. Fairfield Inn & Suites Wentzville

Wentzville

CA $186

CA $213 total

includes taxes & fees

Sep 27 - Sep 28

A spacious lobby with a staircase, a blue sofa, and a wooden table.

A modern interior with a large window, a flat-screen TV mounted on a wall, and a seating area with colorful stools.

A hotel reception desk with a blue water feature design, a sign reading "Quality by Choice Hotels," and a digital screen.

A gym with treadmills, weight machines, and a large potted plant.

19. Quality Inn Foristell

Foristell

CA $120

CA $136 total

includes taxes & fees

Sep 29 - Sep 30

A spacious lobby with a brown leather sofa, multiple chairs, a coffee table with a skull decoration, and a large chandelier.

A large, multi-story hotel with the name "Doubletree by Hilton" prominently displayed on the facade.

An indoor tennis court with multiple courts, a net, and players.

A swimming pool with multiple lanes, surrounded by a fence, and equipped with lounge chairs and a lifeguard stand.

20. DoubleTree by Hilton Hotel St. Louis - Chesterfield

Chesterfield

CA $192

CA $223 total

includes taxes & fees

Sep 27 - Sep 28

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Go beyond your typical stay in Defiance

Pet friendly

Pool

Hot tub

Family friendly

Cottage

Top landmarks in Defiance

A glass of red wine on a wooden table with a vineyard in the background.

Chandler Hill Vineyards

7.8/10 (7 reviews)

Travelers might want a tour of Chandler Hill Vineyards, just one of the places to visit, and located 1.3 mi (2.1 km) from central Defiance.

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A wooden dock extending into a pond with lily pads, surrounded by lush greenery and a clear blue sky.

August A. Busch Memorial Conservation Area

8.6/10 (7 reviews)

If you like spending time outside, why not spend the afternoon at August A. Busch Memorial Conservation Area, a park located 30.2 mi (48.6 km) from the center of St. Louis.

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Sugar Creek Winery

8.0/10 (1 review)

Travelers might want a tour of Sugar Creek Winery, just one of the places to visit, and located 2.2 mi (3.5 km) from central Defiance.

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Historic Daniel Boone Home and Heritage Center

9.6/10 (4 reviews)

Historic Daniel Boone Home and Heritage Center is just one of the landmarks located 4.3 mi (7 km) from central Defiance, so you might want to stop by for a few pics during your trip.

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Yellow Farmhouse Winery

Travelers might want a tour of Yellow Farmhouse Winery, just one of the places to visit in the heart of Defiance.

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Broemmelsiek Park

Broemmelsiek Park is worth a visit, located 6.2 mi (10 km) from central Defiance.

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Matson Hill Park Trailhead

Matson Hill Park Trailhead is 2.1 mi (3.3 km) from central Defiance, why not stop by during your stay.

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Hamburg Trail Trailhead

Hamburg Trail Trailhead is in the heart of Hamburg, so why not stop by during your stay.

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Learn more about Defiance

Defiance is well-known for its attractions such as Yellow Farmhouse Winery and Chandler Hill Vineyards.

See all hotels in Defiance

A rustic covered bridge with a wooden structure and red accents, surrounded by lush greenery and trees.

Check out reviews of Defiance hotels guests love

The Wildwood Hotel

10/10 Excellent

"Very nice hotel. Only concern is the single elevator, since the front desk is on a different level than the bulk of the rooms. Makes for congestion in the morning when housecleaning staff are using it."

Country Inn & Suites by Radisson, St. Charles Historic District

10/10 Excellent

"Friendly staff, clean room, walking distance to shops and restaurants."

Drury Plaza Hotel St. Louis St. Charles

8/10 Good

"Staff is always so friendly at this hotel"

Wingate by Wyndham St. Louis/Fenton Route 66

8/10 Good

"Ok overall, location kind of sketchy"

Hollywood Casino & Hotel St. Louis

10/10 Excellent

"A very cozy stay!"

Ameristar Casino Resort and Spa

10/10 Excellent

"Great, friendly staff. The rooms are clean and it is easy to park."

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

10/10 Excellent

"The hotel was very clean, the check in was pretty easy , and the staff was friendly, if you’re in St. Louis for a night and need a nice clean place to stay they’re great !!"

Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road

10/10 Excellent

"The staff was cool and the area was nice and quiet!"

Frequently asked questions

How much does a hotel room cost in Defiance?

You can discover great hotels in Defiance from CA $110 with properties to suit all budgets and needs. If you're looking for an affordable hotel in Defiance that meets all of your requirements, just sort hotels by "Price: low to high" after applying your filters when searching on Hotels.com.

How can I find deals and earn rewards at Defiance hotels?

Discover great deals on Defiance hotel stays with Hotels.com. Take a look at hotel prices mid-week or during the low season as to find those off-peak deals. If you're up for a spontaneous trip, don't forget to check out our last-minute deals on Defiance hotels.

Can I book Defiance hotels with free cancellation?

It's easy to book a refundable Defiance hotel on Hotels.com. Simply filter hotels by "Property cancellation options" and select "Fully refundable property". The majority of hotels offer free cancellation, so you can receive a refund if you need to cancel. Some hotels do require cancelling more than 24 hours before check-in, so double-check your booking beforehand.

What are some popular hotels in central Defiance?

If you're looking for hotels in central Defiance, check out The Inns at St. Albans near Six Flags. Travelers love The Inns at St. Albans near Six Flags for its location, as well as the garden-view restaurant, golf clubhouse and free parking this inn offers.

Can I book refundable accommodations in Defiance?

If you need the flexibility to change your plans to Defiance, most hotels offer refundable* rates you can book. You can find these accommodations by searching our site and using the "fully refundable" filter to narrow down the results.

What will the weather in Defiance be like during my vacation?

July and August are typically the warmest months in Defiance when the average temp is 76°F. January and February are the coldest months when the average temperature is 38°F. May and April are the months with the most rain.

Why should I book my Defiance hotel through Hotels.com?

There are lots of reasons to book your Defiance trip with us: our free cancellations on selected hotels gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™* on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.