Hotels in Santa Isabel

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Check prices for these dates

Tonight
May 22 - May 23
Tomorrow
May 23 - May 24
This weekend
May 23 - May 25
Next weekend
May 30 - Jun 1

Where to stay in Santa Isabel?

Melincue Casino & Resort
Front of property - evening/night

Melincue Casino & Resort

3.5 star property
8.0 out of 10, Very good, (4)
The price is CA $145
CA $145 total
May 25 - May 26
Melincue Casino & Resort
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
A tranquil hotel pool encircled by beautiful arches

Summer Getaway Sale

Sign in to get 25% or more off selected hotels, plus 1 reward night for every 10 nights you stay. Book by May 26 and travel by Sep 30, 2025. See terms*
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Frequently asked questions

Can I book refundable accommodations in Santa Isabel?
If you’re looking for the flexibility to change your travel plans to Santa Isabel, most properties provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
What will the weather in Santa Isabel be like during my vacation?
January and December are typically the warmest months in Santa Isabel when the average temp is 74°F. July and June are the coldest months when the average temperature is 54°F. January and February are the months with the most rain.
Why should I book my Santa Isabel hotel with Hotels.com?
There are lots of reasons to book your Santa Isabel trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.

Find out more about Santa Isabel

Find out more about Santa Isabel

If you're looking to discover somewhere new, look no further than Santa Isabel. Whether you're planning to stay for a night or for the week, the area around Santa Isabel has accommodations to fit every need. Search for hotels in Santa Isabel with Hotels.com by checking our online map. Our map displays the areas and neighborhoods around all Santa Isabel hotels so you can see how close you are from landmarks and attractions, and then refine your search within the larger area. The best Santa Isabel hotel deals are here with our lowest price guarantee.

Terms and conditions

*Book by 5/26/2025 11:59 pm in hotel property local time. Stay between 4/17/2025-9/30/2025. Member Prices are available to Hotels.com™ app users and Hotels.com™ Rewards members. Limited availability, blackout periods may apply.

Hotels.com Rewards members save more, as compared to non-members shopping on Hotels.com. Members 18+. Eligible properties only. Reward Night worth average daily rate of 10 stamps (excluding taxes/fees). Taxes/fees payable on reward night. Booking exclusions apply, see terms https://ca.hotels.com/lp/b/terms-of-service?pos=HCOM_CA&locale=en_CA.