Hotels in Southern Illinois

Free cancellation options if plans change
Earn rewards on every night you stay
Save more with Member Prices

Check prices for these dates

Tonight
Mar 12 - Mar 13
Tomorrow
Mar 13 - Mar 14
This weekend
Mar 14 - Mar 16
Next weekend
Mar 21 - Mar 23

Where to stay in Southern Illinois?

Drury Plaza Hotel Mt. Vernon
Lobby

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1251)
The price is CA $169
includes taxes & fees
6 Apr - 7 Apr
Drury Plaza Hotel Mt. Vernon
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southern Illinois, IL

Showing deals for:Mar 21 - Mar 23

Image gallery for Makanda Inn

Front of property - evening/night

Makanda Inn

3.5 star property
Makanda
10/10Exceptional (29 reviews)
10% off
Price is CA $380
per night
CA $866 total
includes taxes & fees
Makanda Inn

Top landmarks in Southern Illinois

Southern Illinois University

Southern Illinois University

If you'd like to get a taste of Carbondale student life, check out Southern Illinois University, located 1.1 mi (1.7 km) from central Carbondale.

See properties in Southern Illinois University
Southern Illinois University

Learn more about Southern Illinois

Southern Illinois is applauded for its entertainment and live music with such cultural attractions as Benton Civic Center and Effingham Performance Center. Visitors highlight this family-friendly city's sports while sights include Jefferson County Fairgrounds and Salem Fairgrounds.

See all hotels in Southern Illinois
Southern Illinois featuring a sunset, forests and landscape views
Photo by Southernmost Illinois Tourism Bureau
Open Photo by Southernmost Illinois Tourism Bureau

Frequently asked questions

What accommodations do travelers recommend in Southern Illinois?
Mcgrady Inn, Davie School Inn and Best Western Plus Parkside Inn & Suites are all properties that our guests really like.
Can I book refundable hotels in Southern Illinois?
If you want the flexibility to change your travel plans to Southern Illinois, most accommodations offer refundable* bookable rates. You can find these accommodations by searching our site and using the “fully refundable” filter to narrow down the results.
Which Southern Illinois hotels do guests like for their central location?
Our guests rave about the location of these properties: Comfort Suites Mount Vernon, Drury Inn & Suites Mt. Vernon and Drury Inn & Suites St. Louis Fairview Heights.
Where should I consider staying in Southern Illinois if I want a reasonably priced accommodation?
Comfort Suites Mount Vernon, Baymont by Wyndham Marion and Ramada by Wyndham Effingham are a few accommodations you might want to consider that’ll save you money. You can browse more choices on our site, including 65 motels.
Where can I stay in Southern Illinois if I want a vacation home instead of a traditional hotel?
If you’re looking for a good alternative to a hotel, review our selection of 261 vacation homes. In addition, there are 77 apartments and 6 condos.
Why should I book my Southern Illinois hotel through Hotels.com?
There are plenty of reasons to book your Southern Illinois travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.