Hotels in Greenville

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Check prices for these dates

Tonight
Feb 21 - Feb 22
Tomorrow
Feb 22 - Feb 23
This weekend
Feb 21 - Feb 23
Next weekend
Feb 28 - Mar 2

Where to stay in Greenville?

Learn more about Greenville

The region around Greenville is home to attractions such as Mark Twain National Forest and Lake Wappapello State Park.

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Frequently asked questions

Can I book a refundable hotel in Greenville?
If you need the flexibility to change your plans to Greenville, most properties provide refundable* bookable rates. You can see these properties by searching our site and using the “fully refundable” filter to narrow down the results.
What will the weather in Greenville be like during my trip?
July and August are typically the warmest months in Greenville when the average temp is 77°F. January and February are the coldest months when the average temperature is 41°F. April and May are the months with the most rain.
Why should I book my Greenville hotel through Hotels.com?
There are lots of reasons to book your Greenville trip with us: our free cancellations on selected hotels* gives you flexibility, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.