Hotels in Southeast Missouri

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Where to stay in Southeast Missouri?

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Southeast Missouri

Learn more about Southeast Missouri

Southeast Missouri is well-known for its wineries and riverfront while attractions include Sam A. Baker State Park and K Bridge Recreation Area. This family-friendly city has something for everyone including its university life, restaurants, and sights like Lake Wappapello State Park and Clearwater Lake.

Frequently asked questions

What accommodations do travelers recommend in Southeast Missouri?
Echo Bluff State Park, Hampton Inn Cape Girardeau I 55 East and Hampton Inn Poplar Bluff are all properties that our guests really like.
Can I book a refundable accommodation in Southeast Missouri?
If you need the flexibility to change your travel plans to Southeast Missouri, most hotels provide refundable* rates you can book. You can see these accommodations by searching our site and using the “fully refundable” filter to narrow the results down.
Which Southeast Missouri hotels do our guests like for their great location?
Travelers like these properties for their convenient location: Auburn Place Hotel And Suites, Pear Tree Inn Cape Girardeau Near the Medical Center and Courtyard by Marriott Cape Girardeau Downtown.
Where can I stay in Southeast Missouri if I want a cheap accommodation?
Auburn Place Hotel And Suites, Pear Tree Inn Cape Girardeau Near the Medical Center and Candlewood Suites Cape Girardeau, an IHG Hotel are a few accommodations you might want to consider that’ll save you money. You may want to browse more choices on our site, including 21 motels.
Where can I stay in Southeast Missouri if I want a vacation home instead of a traditional hotel?
If you want a good alternative to a hotel, look over our selection of 129 vacation homes. In addition, there are 46 apartments and 7 condos.
Why should I book my Southeast Missouri accommodation with Hotels.com?
There are plenty of reasons to book your Southeast Missouri travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.