Hotels in Cayo Guillermo

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Where to stay in Cayo Guillermo?

Hotel Grand Muthu Cayo Guillermo
Outdoor pool

Hotel Grand Muthu Cayo Guillermo

3.5 star property
Hotel Grand Muthu Cayo Guillermo
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top landmarks in Cayo Guillermo

Cayo Guillermo Beach

Cayo Guillermo Beach

If being by the water is a major draw, Cayo Guillermo Beach is a spot you might want to check out, located 2.1 mi (3.4 km) from central Cayo Guillermo.

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Cayo Guillermo Beach

Cayo Guillermo Marina

Cayo Guillermo Marina is worth a visit, located 2.6 mi (4.2 km) from central Cayo Guillermo.

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Cayo Guillermo Marina

Learn more about Cayo Guillermo

The region around Cayo Guillermo is home to attractions such as Cayo Guillermo Beach and Cayo Guillermo Marina.

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Frequently asked questions

Can I book a refundable accommodation in Cayo Guillermo?
If you want the flexibility to change your travel plans to Cayo Guillermo, most accommodations provide refundable* bookable rates. You can find these properties by searching our site and using the “fully refundable” filter to narrow the results down.
Where can I stay with my pet in Cayo Guillermo?
Your furry friend can stay with you at this pet-friendly hotel: Sol Cayo Guillermo - All Inclusive.
Where can I stay if I'm visiting Cayo Guillermo with my children?
Parents traveling with children may want to consider Iberostar Daiquirí - All inclusive.
Where should I stay in Cayo Guillermo for a getaway with my partner?
Sol Cayo Guillermo - All Inclusive and Iberostar Daiquirí - All inclusive are great options for a romantic getaway.
Where should I stay in Cayo Guillermo if I want a luxury hotel?
An option for a luxury stay is Iberostar Daiquirí.
What will the weather in Cayo Guillermo be like during my vacation?
With an average temperature of 76°F during the coldest months, Cayo Guillermo is a great place to visit any time of year.
Why should I book my Cayo Guillermo accommodation with Hotels.com?
There are plenty of reasons to book your Cayo Guillermo travel with us: our free cancellations on selected hotels* gives you the flexibility you’re looking for, and with One Key™, our rewards program, you will be able to earn and use OneKeyCash™** on all eligible bookings such as hotels, car rentals, flights, vacation rentals and more on Hotels.com, Expedia and Vrbo.