Marriott Sanibel Harbour Resort & Spa puts you within a 15-minute drive of Key West Express. You can visit the spa to be pampered with deep-tissue massages, body wraps, or aromatherapy, and Tarpon House, one of 4 restaurants, serves American cuisine and is open for breakfast, lunch, and dinner. Other highlights include 3 outdoor pools, an indoor pool, and a bar/lounge. The helpful staff and location get great marks from fellow travelers.