10/10 Exceptional
Very nice hotel. Food is excellent and friendly staff.
Erron
Erron, 2-night trip
Hilton Jacksonville At Mayo Clinic
Luxury hotel in Jacksonville with outdoor pool and restaurant
When you stay at Hilton Jacksonville At Mayo Clinic, you'll be within a 10-minute drive of Mayo Clinic Florida and St. Johns Town Center. The outdoor pool is a great spot to take a dip, and guests can grab a bite to eat at Coastal Kitchen, which serves American cuisine and is open for breakfast, lunch, and dinner. Other highlights at this luxurious hotel include a fitness center and a bar/lounge.
Exceptional
Popular amenities
- Pool
- Free parking
- Free WiFi
- Restaurant
- Air conditioning
- Gym
Main amenities (12)
- Daily housekeeping
- Restaurant and bar/lounge
- Outdoor pool
- Breakfast available
- Free area shuttle
- Fitness center
- Room service
- 12 meeting rooms
- Meeting rooms
- 24-hour front desk
- Air conditioning
- Convenience store
For families (6)
- Children stay free
- Free cribs/infant beds
- Premium TV channels
- Daily housekeeping
- Laundry facilities
- Coffee/tea maker
CA $196
CA $223 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Room options
Check availability for these dates
Showing 20 of 20 rooms
Room, 1 King Bed
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Deluxe Room, 1 King Bed (Water View)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Sofa bed
Blackout drapes/curtains
Premium bedding
- Water view
- Sleeps 2
- 1 King Bed
Deluxe Room, 1 King Bed, Accessible (Roll-In Shower)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Junior Suite, 1 King Bed
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Sofa bed
Blackout drapes/curtains
Premium bedding
- Sleeps 4
- 1 King Bed
Junior Suite, 1 King Bed, Corner
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Sofa bed
Blackout drapes/curtains
Premium bedding
- Sleeps 4
- 1 King Bed
Junior Suite, 1 King Bed, Accessible (Roll-In Shower)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Junior Suite, 1 King Bed, Accessible (Roll-In Shower)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Suite, 1 King Bed, Accessible (Mobility & Hearing, Roll-In Shower)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Room, 1 King Bed (Zero Count)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Room, 1 King Bed (Water View)
Very good
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Water view
- Sleeps 2
- 1 King Bed
Room, 1 King Bed (Water View, Roll-In Shower)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Water view
- Sleeps 2
- 1 King Bed
Room, 1 King Bed, Accessible (Hearing)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Room, 1 King Bed, Accessible (Roll-In Shower)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Room, 1 King Bed, Accessible (Hearing)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 2
- 1 King Bed
Room, 2 Queen Beds
Exceptional
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 4
- 2 Queen Beds
Room, 2 Queen Beds, Accessible (Water View, Hearing)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Water view
- Sleeps 4
- 2 Queen Beds
Room, 2 Queen Beds, Accessible, Bathtub
Exceptional
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 4
- 2 Queen Beds
Room, 2 Queen Beds, Accessible (Hearing)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 4
- 2 Queen Beds
Room, 2 Queen Beds (Water View)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Water view
- Sleeps 4
- 2 Queen Beds
Room, 2 Queen Beds, Accessible, Bathtub (View)
Highlights
Air conditioning
Heating
Free cribs/infant beds
Mini-fridge
Smart TV
Premium bedding
Blackout drapes/curtains
Private bathroom
- Sleeps 4
- 2 Queen Beds
Similar properties
Sheraton Jacksonville Hotel
- Pool
- Pet friendly
- Parking available
- Free WiFi
Wonderful
1,002 reviews
CA $127
CA $144 total
includes taxes & fees
Dec 28 - Dec 29
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
- Pool
- Free breakfast
- Pet friendly
- Free parking
Exceptional
447 reviews
CA $204
CA $231 total
includes taxes & fees
Dec 29 - Dec 30
Hyatt Place Jacksonville / St. Johns Town Center
- Pool
- Pet friendly
- Parking available
- Free WiFi
Wonderful
1,000 reviews
CA $168
CA $191 total
includes taxes & fees
Dec 28 - Dec 29
Hyatt Regency Jacksonville
- Pool
- Pet friendly
- Parking available
- Free WiFi
Wonderful
1,410 reviews
CA $202
CA $232 total
includes taxes & fees
Jan 1 - Jan 2, 2026
Hotel Indigo Jacksonville-Deerwood Park by IHG
- Pool
- Pet friendly
- Free parking
- Free WiFi
Wonderful
1,000 reviews
CA $156
CA $177 total
includes taxes & fees
Dec 28 - Dec 29
Hilton Garden Inn Jacksonville Ponte Vedra Sawgrass
- Pool
- Pet friendly
- Parking available
- Free WiFi
Wonderful
1,006 reviews
CA $157
CA $175 total
includes taxes & fees
Jan 4 - Jan 5, 2026
Marriott Jacksonville
- Pool
- Free parking
- Free WiFi
- Restaurant
Excellent
926 reviews
CA $204
CA $231 total
includes taxes & fees
Dec 28 - Dec 29
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
- Pool
- Free breakfast
- Free parking
- Free WiFi
Exceptional
1,000 reviews
CA $179
CA $203 total
includes taxes & fees
Jan 4 - Jan 5, 2026
TownePlace Suites by Marriott Jacksonville East
- Free breakfast
- Pet friendly
- Free parking
- Free WiFi
Wonderful
548 reviews
CA $156
CA $177 total
includes taxes & fees
Jan 7 - Jan 8, 2026
DoubleTree by Hilton Hotel Jacksonville Riverfront
- Pool
- Pet friendly
- Parking available
- Free WiFi
1,499 reviews
CA $175
CA $199 total
includes taxes & fees
Jan 2 - Jan 3, 2026
Sign in to view eligible discounts and perks. More rewards for more adventures!
About the area
4745 Transformation Way, Jacksonville, FL, 32224
About this property
Hilton Jacksonville At Mayo Clinic
When you stay at Hilton Jacksonville At Mayo Clinic, you'll be within a 10-minute drive of Mayo Clinic Florida and St. Johns Town Center. The outdoor pool is a great spot to take a dip, and guests can grab a bite to eat at Coastal Kitchen, which serves American cuisine and is open for breakfast, lunch, and dinner. Other highlights at this luxurious hotel include a fitness center and a bar/lounge.
At a glance
Property amenities
Room amenities
Special features
Dining
Coastal Kitchen - This restaurant specializes in American cuisine and serves breakfast, lunch, and dinner. Guests can enjoy drinks at the bar. A children's menu is available.
Coastal Kitchen Bar - Onsite cocktail bar. Open daily.
Frequently asked questions
Have a question?
Get instant answers with AI powered search of property information and reviews.
Hilton Jacksonville At Mayo Clinic Reviews
Exceptional
10
Cleanliness
9.6
Amenities
9.6
Staff & service
10
Eco-friendliness
10
Property conditions & facilities
10/10 Exceptional
Staff was friendly. Room was clean. Little wait at checkin. Bed was great!
Jo-Ann
Jo-Ann, 1-night trip
10/10 Exceptional
Room was spotless, new hotel, wonderful friendly staff
Cathy
Cathy, 1-night trip
10/10 Exceptional
Everything was so perfect ! The staff was amazing! Everything was spotless . 10/10 I recommend! I will definitely be back ! 😇
NaJai
NaJai, 2-night trip
4/10 Fair
Arrived at front desk. Three associates engaging in their own conversation. We waited for them to finish and greet us. I finally said “Excuse me, is this where we check-in?”. UNEXCEPTIONABLE NOT the Hilton (or Mayo) experience!!! It made us feel very unwelcome here! This was an isolated incident that applied to the front desk associate only. The room was outstanding (as always) and other associates were very respectful and professional. Going forward, we will reflect on this experience for consideration of hotel stays.
Barbara
Barbara, 1-night trip
10/10 Exceptional
The accommodations were comfortable. Our only "complaint' might be that there needed to be more staff at the front desk in the evening. Because we had an early morning medical appt. we knew we would not be able to have breakfast at the hotel, so we opted to purchase frozen sausage/egg biscuits the night before to heat up in our room. There was no staff at the store at that time and only one at the front desk. The line was 3 deep and we had to wait a long time to pay for these, as the one of the guests in front of us had a lengthy encounter at the desk. Perhaps a self-pay option would be helpful.
Frederick
Frederick, 1-night trip
10/10 Exceptional
It was quite, extremely clean.
Josephine
Josephine, 2-night trip
10/10 Exceptional
Beautiful, comfortable, clean. Restfully furnished. Great service to the Mayo Clinic.
Joseph
Joseph, 3-night trip
10/10 Exceptional
Want to thank the wait staff at bar. They were very helpful and friendly. They made our stressful day much better.
Leslie
Leslie, 1-night trip
10/10 Exceptional
Spotless rooms, very friendly service!
DEBORAH
DEBORAH, 4-night trip
10/10 Exceptional
Gorgeous brand new hotel.
Christine
Christine, 2-night trip
10/10 Exceptional
excellent staff'
Michael
Michael, 1-night trip
10/10 Exceptional
Everything was great
Kamale
Kamale, 3-night trip
10/10 Exceptional
Yes
George E
George E, 1-night trip
8/10 Very good
Hotel was lovely and new. Need to address a couple of things. Trash cans too small; no make up mirror in bathroom; no stool or chair in extremely large bath and no hooks for clothes in bathroom.
Judith
Judith, 2-night trip
4/10 Fair
Something else
DeBora And Edward
DeBora And Edward, 11-night trip
10/10 Exceptional
Yes
EZEKIEL
EZEKIEL, 1-night trip
10/10 Exceptional
O
Ana Helena
Ana Helena, 2-night trip
10/10 Exceptional
Every thing. The staff was phenomenal! The cleanliness was unsurpassed. I loved it. And, I felt safe and my automobile was in a safe location. I loved it!
Linda
Linda, 1-night trip
10/10 Exceptional
Went to Mayo Clinic.
Wonderful place to stay.
Donna
Donna, 1-night trip
10/10 Exceptional
Ruben Dario
Ruben Dario, 1-night trip
2/10 Poor
Barbara
Barbara, 1-night trip
10/10 Exceptional
Matthew
Matthew, 1-night trip
8/10 Very good
juan
juan, 2-night trip
10/10 Exceptional
Janet
Janet, 2-night trip